Figure 6
Downregulation of XIAP attenuated sensitization effect of SH122 on TRAIL-induced cell death. Cells transfected with either XIAP shRNA (A) or the vector control shRNA (B) were treated with serial diluted TRAIL, alone or in combination with 0.1, 1 and 10 μM of SH122, respectively, with 10 μM of SH110 as a negative control. Cytotoxicity was determined by CCK-8 detection kit. Normalized data were presented as mean ± SD (n = 3). Fold of sensitization was calculated by dividing IC50 of the compound-treated group by that of DMSO control.