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Table 2 Genotypes distribution of 8q24 polymorphisms and odds ratios for the minor alleles and genotypes.

From: Association between an 8q24 locus and the risk of colorectal cancer in Japanese

     

Allelic model

Genotype model

     

Model 1 *1

  

Model 2 *2

  

Heterozygote

  

Minor homozygote

  

8q24 locus

 

Genotype

  

OR

95% CI

p-value

ORa

95% CI

p-value

ORa

95% CI

p-value

ORa

95% CI

p-value

rs6983267 (Minor allele: G, MAF*1 in controls = 0.338)

 

TT

TG

GG

UK*4

            

case/control

181/418

222/436

73/107

3/1

1.22

1.04-1.44

0.0144

1.25

1.06-1.48

0.0071

1.19

0.93-1.52

0.1665

1.64

1.15-2.35

0.0063

rs10090154 (Minor allele: T, MAF in controls = 0.153)

 

CC

CT

TT

UK

            

case/control

355/689

112/247

11/23

3/3

0.90

0.72-1.12

0.3443

0.87

0.69-1.09

0.2140

0.83

0.63-1.08

0.1690

0.90

0.43-1.89

0.7854

  1. *1 Crude conditional logistic regression model.
  2. *2 Adjusted for age as continuous variable, drinking (non, low, moderate, heavy, and unknown), smoking (non, moderate, heavy, unknwon), BMI (< 22.5, < 25, < 27.5, 27.5-, unknown), folate in tertile (T1, T2, T3, and unknown), total energy intake, family history of colorectal cancer, average recreational exercise (none, < 0.5 hour/day, 0.5-hour/day) in conditional logisitic regression.
  3. *3 MAF indicates minor allele frequency.
  4. *4 UK indicates the subjects whose genotyping was unsuccessful.