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Table 2 Prostasin Association with the Epithelial Phenotype in Urothelial Cells.

From: Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT)

Urothelial
Cell Lines
Prostasin Protein Levels Prostasin mRNA Levels E-Cadherin Protein Levels E-Cadherin mRNA Levels Morphology (2-D, Plastic) Prostasin
-96 CpG Methylation
EGFR mRNA Levels
UM-UC-9 +++++ +++++++++ +++ +++++++++ Epithelial +/- +++++++
HT-1376 +++++ +++++++++ +++ ++++++ Epithelial - 50× +
UROtsa +++ +++ +++ ++++ Epithelial - > 20× +
UM-UC-5 +++ ++ +++ ++++ Epithelial - > 250× +
UM-UC-10 ++ ++ +++ ++ Epithelial - ++++
UM-UC-14 ++ + +++ ++++++++ Epithelial - +++
RT4 + + +++ +++++++ Epithelial - +++++
KU-7 - - - - Epithelial + ++++
UM-UC-6 - - +++ ++ Mesenchymal + > 10× +
J82 - - - + Mesenchymal + +++++++++
T24 - - - - Mesenchymal + ++
253 J P - - ++ + Mesenchymal + ++++
UM-UC-13 - - - - Mesenchymal + ++++
UM-UC-12 - - + + Mesenchymal + +++++++
253J B-V - - ++ ++ Mesenchymal + > 10× +
UM-UC-3 - - - - Mesenchymal + +++