Table 2 Prostasin Association with the Epithelial Phenotype in Urothelial Cells.
Urothelial Cell Lines | Prostasin Protein Levels | Prostasin mRNA Levels | E-Cadherin Protein Levels | E-Cadherin mRNA Levels | Morphology (2-D, Plastic) | Prostasin -96 CpG Methylation | EGFR mRNA Levels |
|---|---|---|---|---|---|---|---|
UM-UC-9 | +++++ | +++++++++ | +++ | +++++++++ | Epithelial | +/- | +++++++ |
HT-1376 | +++++ | +++++++++ | +++ | ++++++ | Epithelial | - | 50× + |
UROtsa | +++ | +++ | +++ | ++++ | Epithelial | - | > 20× + |
UM-UC-5 | +++ | ++ | +++ | ++++ | Epithelial | - | > 250× + |
UM-UC-10 | ++ | ++ | +++ | ++ | Epithelial | - | ++++ |
UM-UC-14 | ++ | + | +++ | ++++++++ | Epithelial | - | +++ |
RT4 | + | + | +++ | +++++++ | Epithelial | - | +++++ |
KU-7 | - | - | - | - | Epithelial | + | ++++ |
UM-UC-6 | - | - | +++ | ++ | Mesenchymal | + | > 10× + |
J82 | - | - | - | + | Mesenchymal | + | +++++++++ |
T24 | - | - | - | - | Mesenchymal | + | ++ |
253 J P | - | - | ++ | + | Mesenchymal | + | ++++ |
UM-UC-13 | - | - | - | - | Mesenchymal | + | ++++ |
UM-UC-12 | - | - | + | + | Mesenchymal | + | +++++++ |
253J B-V | - | - | ++ | ++ | Mesenchymal | + | > 10× + |
UM-UC-3 | - | - | - | - | Mesenchymal | + | +++ |