Table 6 Pathways targeted by CRC miRNAs
| Â | Â | p-value |
|---|---|---|
Pathway | miRNA targets enriched | Known colon cancer genes |
B Cell Receptor Signaling | 3.02E-08 | 3.16E-07 |
IL-6 Signaling | 4.27E-07 | 1.38E-04 |
Glucocorticoid Receptor Signaling | 7.41E-07 | 6.17E-10 |
ERK/MAPK Signaling | 1.51E-06 | 2.51E-03 |
Ephrin Receptor Signaling | 4.90E-06 | 5.62E-04 |
Ceramide Signaling | 1.02E-05 | 8.32E-07 |
TGF-beta Signaling | 2.63E-05 | 2.04E-06 |
Neurotrophin/TRK Signaling | 3.02E-05 | 1.35E-04 |
Axonal Guidance Signaling | 5.01E-05 | 6.17E-06 |
SAPK/JNK Signaling | 5.37E-05 | 2.24E-02 |
Wnt/beta-catenin Signaling | 6.03E-05 | 1.58E-08 |
Hypoxia Signaling in the Cardiovascular System | 6.61E-05 | 3.55E-02 |
T Cell Receptor Signaling | 8.51E-05 | 2.69E-02 |
p38 MAPK Signaling | 9.77E-05 | 1.20E-03 |
Acute Phase Response Signaling | 2.34E-04 | 4.37E-07 |
Hepatic Fibrosis/Hepatic Stellate Cell Activation | 3.89E-04 | 2.51E-15 |
FGF Signaling | 4.57E-04 | 9.33E-08 |
EGF Signaling | 7.76E-04 | 1.29E-04 |
PPAR Signaling | 8.91E-04 | 5.37E-03 |
PDGF Signaling | 1.00E-03 | 6.03E-05 |
PPARalpha/RXRalpha Activation | 1.23E-03 | 4.90E-04 |
PI3K/AKT Signaling | 1.62E-03 | 1.62E-08 |
Cell Cycle: G1/S Checkpoint Regulation | 2.24E-03 | 2.57E-04 |
Hepatic Cholestasis | 2.24E-03 | 6.92E-03 |
IGF-1 Signaling | 2.88E-03 | 3.31E-05 |
Huntington's Disease Signaling | 5.13E-03 | 1.45E-07 |
Integrin Signaling | 5.13E-03 | 5.37E-04 |
Apoptosis Signaling | 5.62E-03 | 1.26E-11 |
Death Receptor Signaling | 6.17E-03 | 2.82E-09 |
Insulin Receptor Signaling | 7.08E-03 | 5.25E-05 |
Fc Epsilon RI Signaling | 7.24E-03 | 1.38E-09 |
PTEN Signaling | 7.59E-03 | 1.86E-10 |
IL-10 Signaling | 7.94E-03 | 1.74E-02 |
Actin Cytoskeleton Signaling | 1.41E-02 | 9.77E-03 |
Synaptic Long Term Depression | 1.95E-02 | 2.57E-02 |
JAK/Stat Signaling | 2.24E-02 | 6.17E-05 |
NF-kB Signaling | 2.24E-02 | 2.24E-05 |
GM-CSF Signaling | 2.45E-02 | 5.01E-08 |
IL-2 Signaling | 2.57E-02 | 1.41E-05 |
Chemokine Signaling | 3.02E-02 | 5.37E-03 |
VEGF Signaling | 3.02E-02 | 1.38E-07 |
Xenobiotic Metabolism Signaling | 4.37E-02 | 1.78E-02 |