Skip to main content

Table 6 Pathways targeted by CRC miRNAs

From: Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer

   p-value
Pathway miRNA targets enriched Known colon cancer genes
B Cell Receptor Signaling 3.02E-08 3.16E-07
IL-6 Signaling 4.27E-07 1.38E-04
Glucocorticoid Receptor Signaling 7.41E-07 6.17E-10
ERK/MAPK Signaling 1.51E-06 2.51E-03
Ephrin Receptor Signaling 4.90E-06 5.62E-04
Ceramide Signaling 1.02E-05 8.32E-07
TGF-beta Signaling 2.63E-05 2.04E-06
Neurotrophin/TRK Signaling 3.02E-05 1.35E-04
Axonal Guidance Signaling 5.01E-05 6.17E-06
SAPK/JNK Signaling 5.37E-05 2.24E-02
Wnt/beta-catenin Signaling 6.03E-05 1.58E-08
Hypoxia Signaling in the Cardiovascular System 6.61E-05 3.55E-02
T Cell Receptor Signaling 8.51E-05 2.69E-02
p38 MAPK Signaling 9.77E-05 1.20E-03
Acute Phase Response Signaling 2.34E-04 4.37E-07
Hepatic Fibrosis/Hepatic Stellate Cell Activation 3.89E-04 2.51E-15
FGF Signaling 4.57E-04 9.33E-08
EGF Signaling 7.76E-04 1.29E-04
PPAR Signaling 8.91E-04 5.37E-03
PDGF Signaling 1.00E-03 6.03E-05
PPARalpha/RXRalpha Activation 1.23E-03 4.90E-04
PI3K/AKT Signaling 1.62E-03 1.62E-08
Cell Cycle: G1/S Checkpoint Regulation 2.24E-03 2.57E-04
Hepatic Cholestasis 2.24E-03 6.92E-03
IGF-1 Signaling 2.88E-03 3.31E-05
Huntington's Disease Signaling 5.13E-03 1.45E-07
Integrin Signaling 5.13E-03 5.37E-04
Apoptosis Signaling 5.62E-03 1.26E-11
Death Receptor Signaling 6.17E-03 2.82E-09
Insulin Receptor Signaling 7.08E-03 5.25E-05
Fc Epsilon RI Signaling 7.24E-03 1.38E-09
PTEN Signaling 7.59E-03 1.86E-10
IL-10 Signaling 7.94E-03 1.74E-02
Actin Cytoskeleton Signaling 1.41E-02 9.77E-03
Synaptic Long Term Depression 1.95E-02 2.57E-02
JAK/Stat Signaling 2.24E-02 6.17E-05
NF-kB Signaling 2.24E-02 2.24E-05
GM-CSF Signaling 2.45E-02 5.01E-08
IL-2 Signaling 2.57E-02 1.41E-05
Chemokine Signaling 3.02E-02 5.37E-03
VEGF Signaling 3.02E-02 1.38E-07
Xenobiotic Metabolism Signaling 4.37E-02 1.78E-02