Figure 1

Two-way hierarchical clustering of CRC and normal colorectal tissue using 37 differentially expressed miRNAs. The hypergeometric mean of the log2 signal intensity was calculated across all samples using a euclidean distance metric with complete linkage. Red and blue indicates miRNAs expressed at a high or low level relative to other samples in the dataset, respectively. The miR-143-145 and miR-17-92 clusters are indicated by vertical blue and red bars, respectively. Samples are grouped into two main clusters: Cluster I primarily represents normal colorectal tissue, and clusters II represents CRC samples. Replicate samples are indicated by the suffix "2".