Functional analysis of MSX2. (A) Heat-map of selected pathway-genes. Expression data obtained by profiling of JURKAT cells transduced with empty vector and MSX2, respectively, were transformed into a heat-map, demonstrating differential gene activities. (B) Quantitative real-time PCR expression analysis of 16 candidate target genes was performed in JURKAT cells transduced with MSX2, TLX1 or NKX2-5, respectively, in comparison to vector controls. Expression of TBP served as endogenous control.