Figure 3From: Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis OGF is the specific opioid peptide involved in the growth inhibition of human anaplastic thyroid cancer cells. (A) The effects of various endogenous and exogenous opioids (10-6 M) or sterile water (Co) on KAT-18 cell number. (B) Cells were treated with an antibody specific for OGF (CO172), pre-immune serum (IgG), exogenous OGF (10-6 M), or sterile water (Co). Cell number was measured at 72 h. Data for both experiments represent mean SE for at least 2 aliquots/well from 2 wells/group. Three experiments were conducted for each measure. Significantly different from respective controls at p < 0.01 (**) or p < 0.001 (***).Back to article page