Table 5 Multinomial logistic regression model: Prediction of Response (second-line)

Age > 65 years

0.392

0.35

0.03-3.9

Age < 35 years

0.363

0.3

0.02-4

Stage 4 at diagnosis

0.839

1.11

0.4-3.14

Grading (1,2 versus 3)

0.268

0.37

0.06-2.15

Histologic type (ductal versus lobular)

0.19

0.17

0.01-2.41

Positive hormone receptor status

0.534

0.63

0.15-2.68

Time to recurrence < 12 months

0.332

0.43

0.08-2.36

Visceral metastases

0.147

3.96

0.62-25-35

Number of metastatic sites (1 versus 2)

0.318

0.36

0.05-2.64

Number of metastatic sites (2 versus > 2)

0.792

0.82

0.18-3.63

Trastuzumab from first-line palliative treatment

0.886

1.15

0.18-7.53

Response to fist-line trastuzumab-based therapy

0.201

2.58

0.6-11-08

New metastatic sites at progression upon first-line trastuzumab-based therapy

0.953

1.04

0.28-3.84