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Table 2 BRCA2 group and IHC tumour characteristics.

From: Selecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers

ID pts

Age at diagnosis

DNA

Mutation effect

Grade

° ER (score)

° PR (score)

§HER2

^ BRCAPRO BRCA1

^ BRCAPRO BRCA2

^ BRCAPRO total

*BC, CBC and BBC cases

*OC cases

BR288

36

9326insA

3043X

3

+ (6)

+ (5)

1+

0.003

0.026

0.029

/

1 (44)

BR295

54

657insC

157X

2

+ (8)

+ (5)

-

0.029

0.405

0.434

2 (41+43 CBC, 48)

/

BR312

47

IVS16-2A>G

Exon skipping

3

+ (5)

+ (3)

1+

0.002

0.365

0.367

2 (47, 77 M)

/

BR342

44+52 CBC

9106C>T

Q2960X

3

+ (8)

+ (3)

2+

0.006

0.182

0.187

2 (59, 68+75 CBC)

/

BR360

43

IVS23+1G>T

Exon skipping

3

+ (4)

+ (6)

2+/3+

0.088

0.553

0.640

1 (30 BBC)

/

BR382

44+63 CBC

7507del7

2168X

3

+ (6)

+ (8)

1+

0.002

0.061

0.063

1 (35)

/

BR410

24

9325delA

3061X

2

+ (7)

+ (4)

1+

0.170

0.557

0.727

1 (47)

2 (54, 73)

BR450

48

4450C>T

Q1408X

1

+ (7)

+ (7)

-

0.010

0.044

0.054

2 (52, 55)

2 (38, 55)

BR571

31

3036del4

959X

2

+ (3)

+ (6)

3+

0.001

0.037

0.038

3 (50, 50, 61)

/

  1. BC = breast cancer; CBC = controlateral breast cancer; BBC = bilateral breast cancer; OC = ovarian cancer; / = no cases; M = male. ° IHC Allred total scores of 3 or more were reported as positive. §HER2 IHC scores: - negative, 1+ weak, 2+ moderate, 3+ strong. ^ Probability of mutation calculated by BRCAPRO Software http://www.isds.duke.edu/~gp/brcapro.html; * number of additional tumours in the family and ages of onset in parentheses.