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Table 2 BRCA2 group and IHC tumour characteristics.

From: Selecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers

ID pts Age at diagnosis DNA Mutation effect Grade ° ER (score) ° PR (score) §HER2 ^ BRCAPRO BRCA1 ^ BRCAPRO BRCA2 ^ BRCAPRO total *BC, CBC and BBC cases *OC cases
BR288 36 9326insA 3043X 3 + (6) + (5) 1+ 0.003 0.026 0.029 / 1 (44)
BR295 54 657insC 157X 2 + (8) + (5) - 0.029 0.405 0.434 2 (41+43 CBC, 48) /
BR312 47 IVS16-2A>G Exon skipping 3 + (5) + (3) 1+ 0.002 0.365 0.367 2 (47, 77 M) /
BR342 44+52 CBC 9106C>T Q2960X 3 + (8) + (3) 2+ 0.006 0.182 0.187 2 (59, 68+75 CBC) /
BR360 43 IVS23+1G>T Exon skipping 3 + (4) + (6) 2+/3+ 0.088 0.553 0.640 1 (30 BBC) /
BR382 44+63 CBC 7507del7 2168X 3 + (6) + (8) 1+ 0.002 0.061 0.063 1 (35) /
BR410 24 9325delA 3061X 2 + (7) + (4) 1+ 0.170 0.557 0.727 1 (47) 2 (54, 73)
BR450 48 4450C>T Q1408X 1 + (7) + (7) - 0.010 0.044 0.054 2 (52, 55) 2 (38, 55)
BR571 31 3036del4 959X 2 + (3) + (6) 3+ 0.001 0.037 0.038 3 (50, 50, 61) /
  1. BC = breast cancer; CBC = controlateral breast cancer; BBC = bilateral breast cancer; OC = ovarian cancer; / = no cases; M = male. ° IHC Allred total scores of 3 or more were reported as positive. §HER2 IHC scores: - negative, 1+ weak, 2+ moderate, 3+ strong. ^ Probability of mutation calculated by BRCAPRO Software http://www.isds.duke.edu/~gp/brcapro.html; * number of additional tumours in the family and ages of onset in parentheses.