Skip to main content

Table 1 BRCA1 group and IHC tumour characteristics.

From: Selecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers

ID pts

Age at diagnosis

DNA

Mutation effect

Grade

° ER (score)

° PR (score)

§HER2

^ BRCAPRO BRCA1

^ BRCAPRO BRCA2

^ BRCAPRO total

*BC and CBC cases

*OC cases

BR332

42

633delC

233X

3

- (2)

- (0)

-

0.975

0.013

0.987

1 (27)

2 (35, 56)

BR334

26

2428C>A

S770X

3

- (0)

- (0)

-

0.658

0.091

0.748

1 (53)

1 (75)

BR341

45

del 9-19

del ex. 9-19 ter 184

3

- (0)

- (0)

-

0.320

0.524

0.841

3 (37, 48 M, 52)

/

BR352

37

del 23-24

unpredictable

3

- (0)

- (0)

1+

0.777

0.075

0.850

1 (29+42 CBC)

/

BR384

50+56 CBC

795delT

233X

3

- (0)

- (0)

1+/2+

0.529

0.085

0.613

2 (56, 57)

1 (57)

BR386

40

1806C>T

Q563X

3

- (0)

- (0)

1+/2+

0.311

0.048

0.358

/

1 (69)

BR392

31

795delT

233X

3

- (0)

- (0)

-

0.813

0.066

0.876

1 (46+48 CBC)

/

BR441

46

5181delGTT

1688delV

3

- (0)

- (0)

-

0.166

0.036

0.202

3 (46, 47, 48)

1 (63)

BR507

22

633delC

233X

3

- (0)

- (0)

1+

0.091

0.015

0.106

/

/

BR587

38+60 CBC

300T>G

C61G

3

- (0)

- (0)

1+

0.922

0.063

0.984

2 (40, 43)

1 (60)

  1. BC = breast cancer; CBC = controlateral breast cancer; OC = ovarian cancer; / = no cases; M = male. The ages at diagnosis of the first cousins are in boldface type; ° IHC Allred total scores of 3 or more were reported as positive. §HER2 IHC scores: - negative, 1+ weak, 2+ moderate, 3+ strong. ^ Probability of mutation calculated by BRCAPRO software http://www.isds.duke.edu/~gp/brcapro.html; * number of additional tumours in the family and ages of onset in parentheses.