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Table 1 BRCA1 group and IHC tumour characteristics.

From: Selecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers

ID pts Age at diagnosis DNA Mutation effect Grade ° ER (score) ° PR (score) §HER2 ^ BRCAPRO BRCA1 ^ BRCAPRO BRCA2 ^ BRCAPRO total *BC and CBC cases *OC cases
BR332 42 633delC 233X 3 - (2) - (0) - 0.975 0.013 0.987 1 (27) 2 (35, 56)
BR334 26 2428C>A S770X 3 - (0) - (0) - 0.658 0.091 0.748 1 (53) 1 (75)
BR341 45 del 9-19 del ex. 9-19 ter 184 3 - (0) - (0) - 0.320 0.524 0.841 3 (37, 48 M, 52) /
BR352 37 del 23-24 unpredictable 3 - (0) - (0) 1+ 0.777 0.075 0.850 1 (29+42 CBC) /
BR384 50+56 CBC 795delT 233X 3 - (0) - (0) 1+/2+ 0.529 0.085 0.613 2 (56, 57) 1 (57)
BR386 40 1806C>T Q563X 3 - (0) - (0) 1+/2+ 0.311 0.048 0.358 / 1 (69)
BR392 31 795delT 233X 3 - (0) - (0) - 0.813 0.066 0.876 1 (46+48 CBC) /
BR441 46 5181delGTT 1688delV 3 - (0) - (0) - 0.166 0.036 0.202 3 (46, 47, 48) 1 (63)
BR507 22 633delC 233X 3 - (0) - (0) 1+ 0.091 0.015 0.106 / /
BR587 38+60 CBC 300T>G C61G 3 - (0) - (0) 1+ 0.922 0.063 0.984 2 (40, 43) 1 (60)
  1. BC = breast cancer; CBC = controlateral breast cancer; OC = ovarian cancer; / = no cases; M = male. The ages at diagnosis of the first cousins are in boldface type; ° IHC Allred total scores of 3 or more were reported as positive. §HER2 IHC scores: - negative, 1+ weak, 2+ moderate, 3+ strong. ^ Probability of mutation calculated by BRCAPRO software http://www.isds.duke.edu/~gp/brcapro.html; * number of additional tumours in the family and ages of onset in parentheses.