Figure 1

Time dependent DNA damage (black square) presented as median with first and third quartile and cytotoxicity (black triangle) presented as mean with standard deviation induced by 100% SPK cisplatin (A), or 100% SPK carboplatin (B) in primary ovarian carcinoma cells. DNA damage is shown as reduction of MMS induced tail moments (tm) by the platinum compound (50 comets/sample evaluated). MMS alone induced a tail moment ranging from 80-90. The platinum compounds alone induced no tail moments.