Table 1 Promoter methylation of genes in Oral cancer

TSC2

Oral squamous cell carcinoma (OSCC)

COBRA

[44]

CDKN2A, p14ARF

OSCC

MSP

[10]

MGMT

Head & Neck squamous cell carcinoma (HNSCC)

MSP

[3]

RASSF1A

Betal-associated oral carcinoma

MSP

[13]

p16INK4a, p15, MLH1, MGMT, E-CADHERIN

OSCC

Restriction multiplex PCR

[29]

p16INK4a, RASSF1A, DAPK

Salivary adenoid cystic carcinoma

MSP

[30]

MGMT

HNSCC

MSP

[21]

p16INK4a

HNSCC

MSP

[22]

MGMT, p16INK4a, MLH1

HNSCC

MSP

[23]

CNKN2, CDH1, MGMT, DAPK, DBC1, p14, CDKN2B, RARB, RASSF1A, MLH1, p73, DCC, FHIT, SERPINB5

HNSCC &/or OSCC

MSP, PCR-based restriction assay and/or bisulfite sequencing

[11]

p16INK4a, CYCLIN A1, RARB, E-CADHERIN, MGMT, STAT1, ATM, MLH1, TIMP3

SCC of the oral cavity or oropharynx

pryosequencing

[26]

RASSF2

OSCC

MSP

[45]

RECK

OSCC

MSP

[46]

ATM

HNSCC

MSP

[47]

p16INK4a, CYTOGLOBIN, CYCLIN A1

OSCC

pyrosequencing

[35]

MLH1

HNSCC

MSP

[15]

p16INK4a, MGMT, DAPK, E-CADHERIN

Laryngeal and hypopharyngeal cancer

MSP

[24]

CYTOGLOBIN

Oral or oropharyngeal squamous cell carcinoma

pyrosequencing

[48]

RIZ1

Nasopharyngeal carcinoma

MSP

[49]

CDKN2A

OSCC

[50]

p16INK4a, p14ARF, MGMT, RB1, PTEN, p27KIP1

OSCC

MSP

[51]

APC

OSCC

MSP

[52]

CDH1

HNSCC

MSP

[53]

p16INK4a, DAPK, E-CADHERIN, RASSF1A

HNSCC

MSP

[54]

TIMP3, CDH1

HNSCC

MSP

[55]

p16INK4a

Oral epithelial dysplasia

MSP

[56]

RARB, MGMT, RASSF1, E-CADHERIN

Salivary gland carcinoma

pyrosequencing

[57]

MGMT, p16INK4a

OSCC

MSP

[31]

RASSF1A, RASSF2A, HIN-1

OSCC

PCR-denaturing HPLC

[12]

MLH1, MSH2

OSCC

MSP

[58]

RUNX3

OSCC

MSP

[59]

LINE-1

OSCC

COBRALINE-1

[60]

SFRP1, SFRP2, SFRP5

OSCC

MSP

[61]

miR-137

OSCC

COBRA and bisulfite sequencing

[62]