Skip to main content

Advertisement

Table 1 Promoter methylation of genes in Oral cancer

From: Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation

Gene Cancer type Method for methylation analysis Reference
TSC2 Oral squamous cell carcinoma (OSCC) COBRA [44]
CDKN2A, p14ARF OSCC MSP [10]
MGMT Head & Neck squamous cell carcinoma (HNSCC) MSP [3]
RASSF1A Betal-associated oral carcinoma MSP [13]
p16INK4a, p15, MLH1, MGMT, E-CADHERIN OSCC Restriction multiplex PCR [29]
p16INK4a, RASSF1A, DAPK Salivary adenoid cystic carcinoma MSP [30]
MGMT HNSCC MSP [21]
p16INK4a HNSCC MSP [22]
MGMT, p16INK4a, MLH1 HNSCC MSP [23]
CNKN2, CDH1, MGMT, DAPK, DBC1, p14, CDKN2B, RARB, RASSF1A, MLH1, p73, DCC, FHIT, SERPINB5 HNSCC &/or OSCC MSP, PCR-based restriction assay and/or bisulfite sequencing [11]
p16INK4a, CYCLIN A1, RARB, E-CADHERIN, MGMT, STAT1, ATM, MLH1, TIMP3 SCC of the oral cavity or oropharynx pryosequencing [26]
RASSF2 OSCC MSP [45]
RECK OSCC MSP [46]
ATM HNSCC MSP [47]
p16INK4a, CYTOGLOBIN, CYCLIN A1 OSCC pyrosequencing [35]
MLH1 HNSCC MSP [15]
p16INK4a, MGMT, DAPK, E-CADHERIN Laryngeal and hypopharyngeal cancer MSP [24]
CYTOGLOBIN Oral or oropharyngeal squamous cell carcinoma pyrosequencing [48]
RIZ1 Nasopharyngeal carcinoma MSP [49]
CDKN2A OSCC   [50]
p16INK4a, p14ARF, MGMT, RB1, PTEN, p27KIP1 OSCC MSP [51]
APC OSCC MSP [52]
CDH1 HNSCC MSP [53]
p16INK4a, DAPK, E-CADHERIN, RASSF1A HNSCC MSP [54]
TIMP3, CDH1 HNSCC MSP [55]
p16INK4a Oral epithelial dysplasia MSP [56]
RARB, MGMT, RASSF1, E-CADHERIN Salivary gland carcinoma pyrosequencing [57]
MGMT, p16INK4a OSCC MSP [31]
RASSF1A, RASSF2A, HIN-1 OSCC PCR-denaturing HPLC [12]
MLH1, MSH2 OSCC MSP [58]
RUNX3 OSCC MSP [59]
LINE-1 OSCC COBRALINE-1 [60]
SFRP1, SFRP2, SFRP5 OSCC MSP [61]
miR-137 OSCC COBRA and bisulfite sequencing [62]