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Table 2 Distribution of germline mutations in p16CDKN2Aand BRCA2 genes according to patients' origin

From: Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy

Analyzed gene
Patients' origin
No. of analyzed patients Positive cases
   No. %
CDKN2A 846 16 1.9
   non-Sardinian 545 16 2.9
Familial 35 6 17.1
Sporadic 510 10 2.0
Sardinian 301 0
Familial 10 0
Sporadic 291 0
BRCA2 455 4 0.9
   non-Sardinian 154 0
Sardinian 301 4 1.3
North Sardinia 91 4 4.4
Familial 4 1 25.0
Sporadic 87 3 3.4
Middle-South Sardinia 210 0
Familial 6 0
Sporadic 204 0