The association between RCAS1 expression in laryngeal and pharyngeal cancer and its healthy stroma with cancer relapse

Table 2 RCAS1 immunoreactivity in pharyngeal and laryngeal cancer and clear surgical margin derived from the same individuals.

		RCAS1 immunoreactivity
Variables	Number	-	+1	+2	+3
Pharyngeal and laryngeal squamous cell carcinoma	51	0	0	22 (44%)	29 (56%)
Clear surgical margin	51	1 (3.5%)	24 (44.5%)*	25 (48.5%)*	1 (3.5%)

*The change in the intensity of immunoreactivity was observed in six specimens (12%), in one case in the group of the +1 RCAS1 immunoreactivity and in 5 cases in the group of +2 RCAS1 immunoreactivity; the expression decreased with the distance from cancer cells. In four examined samples, the RCAS1 immunoreactivity level in closely tumor-adjacent tissue was established as moderate and decreasing to weak in the line of resection. In two cases, weak RCAS1 immunoreactivity in the directly tumor-adjacent tissue diminished to the point of absence in the resection line.