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Table 7 Multivariate adjusted relative risk (RR)* and 95% confidence intervals (CI) for the association of light physical activity during four periods of life with breast cancer tumor characteristics: 118,899 postmenopausal women in the NIH-AARP Diet and Health Study

From: Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP Diet and Health Study

Moderate/vigorous activity ER-positive
RR
95%
CI
ER-
negative
RR
95%
CI
p†† ER-
unknown
RR
95%
CI
p§ Invasive
RR
95%
CI
In
situ
RR
95%
CI
p£
Ages 15-18 years                   
   Never/Rarely 1.00 (ref.)    1.00 (ref.)     1.00 (ref.)     1.00 (ref.)    1.00 (ref.)    
   <1 hour/week 1.05 0.82 1.34 0.85 0.48 1.49   1.08 0.89 1.31   1.05 0.91 1.22 1.40 1.04 1.87  
   1-3 hours/week 1.10 0.90 1.34 1.11 0.73 1.68   0.96 0.82 1.13   1.02 0.91 1.15 1.20 0.93 1.53  
   4-7 hours/week 1.22 1.00 1.47 0.98 0.64 1.50   0.94 0.80 1.10   1.04 0.93 1.17 0.90 0.70 1.17  
   >7 hours/week 1.18 0.98 1.42 0.91 0.61 1.36 0.24 1.02 0.88 1.18 0.33 1.06 0.95 1.19 0.89 0.70 1.17 0.18
Ages 19-29 years                   
   Never/Rarely 1.00 (ref.)    1.00 (ref.)     1.00 (ref.)     1.00 (ref.)    1.00 (ref.)    
   <1 hour/week 1.18 0.92 1.52 0.99 0.56 1.76   1.01 0.82 1.24   1.07 0.92 1.25 1.12 0.81 1.54  
   1-3 hours/week 1.14 0.92 1.41 0.90 0.56 1.44   0.99 0.84 1.18   1.04 0.91 1.18 1.14 0.87 1.49  
   4-7 hours/week 1.16 0.94 1.43 1.15 0.74 1.80   0.94 0.79 1.11   1.03 0.91 1.17 0.94 0.71 1.23  
   >7 hours/week 1.14 0.93 1.40 0.96 0.61 1.49 0.48 0.99 0.84 1.16 0.51 1.04 0.92 1.18 0.87 0.67 1.13 0.23
Ages 35-39 years                   
   Never/Rarely 1.00 (ref.)    1.00 (ref.)     1.00 (ref.)     1.00 (ref.)    1.00 (ref.)    
   <1 hour/week 1.17 0.91 1.49 0.93 0.51 1.71   1.03 0.83 1.27   1.07 0.92 1.25 1.23 0.90 1.68  
   1-3 hours/week 0.99 0.80 1.23 1.25 0.77 2.02   0.95 0.79 1.13   0.99 0.86 1.12 0.99 0.75 1.30  
   4-7 hours/week 1.08 0.88 1.33 1.14 0.71 1.84   1.03 0.87 1.22   1.06 0.93 1.20 0.92 0.70 1.21  
   >7 hours/week 1.01 0.82 1.24 1.01 0.63 1.63 0.99 0.99 0.83 1.17 0.99 1.00 0.88 1.13 0.85 0.65 1.12 0.31
Past 10 years                   
   Never/Rarely 1.00 (ref.)    1.00 (ref.)     1.00 (ref.)     1.00 (ref.)    1.00 (ref.)    
   <1 hour/week 1.18 0.97 1.45 0.60 0.35 1.03   1.00 0.84 1.19   1.04 0.91 1.18 1.12 0.85 1.49  
   1-3 hours/week 0.96 0.80 1.14 0.79 0.53 1.17   0.88 0.76 1.01   0.90 0.81 1.00 0.99 0.78 1.25  
   4-7 hours/week 0.98 0.83 1.17 0.99 0.68 1.45   0.87 0.75 1.01   0.92 0.83 1.03 0.90 0.71 1.14  
   >7 hours/week 0.77 0.64 0.92 0.87 0.58 1.29 0.58 0.89 0.77 1.03 0.56 0.84 0.75 0.94 0.85 0.66 1.08 0.96
No. cancer cases** 1352    263     1907     3522    736    
  1. * Relative risks adjusted for: age (continuous); race/ethnicity (white, black, Hispanic, Asian/Pacific Islander/American Indian); education level (<12 years or high school equivalent, 12 years or high school equivalent, post-high school vocational or technical training, some college, college graduate, post-graduate); smoking status (non-smoker, former, current); alcohol intake (grams/day, quintiles adjusted for total energy intake); family history of breast cancer (no, yes); age at menarche (<13, 13-14, ≥ 15 years); age at first birth (nulliparous, <20, 20-24, 25-29, 30+ years); parity (number of children: 0, 1-2, 3 or more); age at menopause (<40, 40-44, 45-49, 50-54, ≥ 55 years); menopausal hormone use (never, ever)
  2. ** Total numbers of cancer cases may vary due to missing physical activity values.
  3. † ER: estrogen receptor. Hormone receptor status limited to invasive cancers.
  4. †† p-value for heterogeneity comparing RR for >7 hours/week of physical activity: ER-positive and ER-negative tumors.
  5. §p-value for heterogeneity comparing RR for >7 hours/week of physical activity: ER-positive, ER-negative, and ER-unknown tumors.
  6. £ p-value for heterogeneity comparing RR for >7 hours/week of physical activity: invasive and in situ tumors