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Table 7 Multivariate adjusted relative risk (RR)* and 95% confidence intervals (CI) for the association of light physical activity during four periods of life with breast cancer tumor characteristics: 118,899 postmenopausal women in the NIH-AARP Diet and Health Study

From: Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP Diet and Health Study

Moderate/vigorous activity

ER-positive

†RR

95%

CI

ER-

negative

RR

95%

CI

p††

ER-

unknown

RR

95%

CI

p§

Invasive

RR

95%

CI

In

situ

RR

95%

CI

p£

Ages 15-18 years

                  

   Never/Rarely

1.00 (ref.)

  

1.00 (ref.)

   

1.00 (ref.)

   

1.00 (ref.)

  

1.00 (ref.)

   

   <1 hour/week

1.05

0.82

1.34

0.85

0.48

1.49

 

1.08

0.89

1.31

 

1.05

0.91

1.22

1.40

1.04

1.87

 

   1-3 hours/week

1.10

0.90

1.34

1.11

0.73

1.68

 

0.96

0.82

1.13

 

1.02

0.91

1.15

1.20

0.93

1.53

 

   4-7 hours/week

1.22

1.00

1.47

0.98

0.64

1.50

 

0.94

0.80

1.10

 

1.04

0.93

1.17

0.90

0.70

1.17

 

   >7 hours/week

1.18

0.98

1.42

0.91

0.61

1.36

0.24

1.02

0.88

1.18

0.33

1.06

0.95

1.19

0.89

0.70

1.17

0.18

Ages 19-29 years

                  

   Never/Rarely

1.00 (ref.)

  

1.00 (ref.)

   

1.00 (ref.)

   

1.00 (ref.)

  

1.00 (ref.)

   

   <1 hour/week

1.18

0.92

1.52

0.99

0.56

1.76

 

1.01

0.82

1.24

 

1.07

0.92

1.25

1.12

0.81

1.54

 

   1-3 hours/week

1.14

0.92

1.41

0.90

0.56

1.44

 

0.99

0.84

1.18

 

1.04

0.91

1.18

1.14

0.87

1.49

 

   4-7 hours/week

1.16

0.94

1.43

1.15

0.74

1.80

 

0.94

0.79

1.11

 

1.03

0.91

1.17

0.94

0.71

1.23

 

   >7 hours/week

1.14

0.93

1.40

0.96

0.61

1.49

0.48

0.99

0.84

1.16

0.51

1.04

0.92

1.18

0.87

0.67

1.13

0.23

Ages 35-39 years

                  

   Never/Rarely

1.00 (ref.)

  

1.00 (ref.)

   

1.00 (ref.)

   

1.00 (ref.)

  

1.00 (ref.)

   

   <1 hour/week

1.17

0.91

1.49

0.93

0.51

1.71

 

1.03

0.83

1.27

 

1.07

0.92

1.25

1.23

0.90

1.68

 

   1-3 hours/week

0.99

0.80

1.23

1.25

0.77

2.02

 

0.95

0.79

1.13

 

0.99

0.86

1.12

0.99

0.75

1.30

 

   4-7 hours/week

1.08

0.88

1.33

1.14

0.71

1.84

 

1.03

0.87

1.22

 

1.06

0.93

1.20

0.92

0.70

1.21

 

   >7 hours/week

1.01

0.82

1.24

1.01

0.63

1.63

0.99

0.99

0.83

1.17

0.99

1.00

0.88

1.13

0.85

0.65

1.12

0.31

Past 10 years

                  

   Never/Rarely

1.00 (ref.)

  

1.00 (ref.)

   

1.00 (ref.)

   

1.00 (ref.)

  

1.00 (ref.)

   

   <1 hour/week

1.18

0.97

1.45

0.60

0.35

1.03

 

1.00

0.84

1.19

 

1.04

0.91

1.18

1.12

0.85

1.49

 

   1-3 hours/week

0.96

0.80

1.14

0.79

0.53

1.17

 

0.88

0.76

1.01

 

0.90

0.81

1.00

0.99

0.78

1.25

 

   4-7 hours/week

0.98

0.83

1.17

0.99

0.68

1.45

 

0.87

0.75

1.01

 

0.92

0.83

1.03

0.90

0.71

1.14

 

   >7 hours/week

0.77

0.64

0.92

0.87

0.58

1.29

0.58

0.89

0.77

1.03

0.56

0.84

0.75

0.94

0.85

0.66

1.08

0.96

No. cancer cases**

1352

  

263

   

1907

   

3522

  

736

   
  1. * Relative risks adjusted for: age (continuous); race/ethnicity (white, black, Hispanic, Asian/Pacific Islander/American Indian); education level (<12 years or high school equivalent, 12 years or high school equivalent, post-high school vocational or technical training, some college, college graduate, post-graduate); smoking status (non-smoker, former, current); alcohol intake (grams/day, quintiles adjusted for total energy intake); family history of breast cancer (no, yes); age at menarche (<13, 13-14, ≥ 15 years); age at first birth (nulliparous, <20, 20-24, 25-29, 30+ years); parity (number of children: 0, 1-2, 3 or more); age at menopause (<40, 40-44, 45-49, 50-54, ≥ 55 years); menopausal hormone use (never, ever)
  2. ** Total numbers of cancer cases may vary due to missing physical activity values.
  3. † ER: estrogen receptor. Hormone receptor status limited to invasive cancers.
  4. †† p-value for heterogeneity comparing RR for >7 hours/week of physical activity: ER-positive and ER-negative tumors.
  5. §p-value for heterogeneity comparing RR for >7 hours/week of physical activity: ER-positive, ER-negative, and ER-unknown tumors.
  6. £ p-value for heterogeneity comparing RR for >7 hours/week of physical activity: invasive and in situ tumors
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BMC Cancer

ISSN: 1471-2407

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