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Table 6 Multivariate adjusted relative risk (RR)* and 95% confidence intervals (CI) for the association of light physical activity during four periods of life with breast cancer tumor characteristics: 118,899 postmenopausal women in the NIH-AARP Diet and Health Study

From: Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP Diet and Health Study

Light activity

ER-

positive

†RR

95%

CI

ER-

negative

RR

95%

CI

p††

ER-

unknown

RR

95%

CI

p§

Invasive

RR

95%

CI

In

situ

RR

95%

CI

p£

Ages 15-18 years

                  

   Never/Rarely

1.00 (ref.)

  

1.00 (ref.)

   

1.00 (ref.)

   

1.00 (ref.)

  

1.00 (ref.)

   

   <1 hour/week

0.99

0.75

1.29

1.03

0.56

1.90

 

1.28

1.03

1.60

 

1.14

0.97

1.35

0.90

0.63

1.27

 

   1-3 hours/week

0.97

0.78

1.21

1.07

0.65

1.74

 

1.10

0.91

1.33

 

1.04

0.91

1.20

1.06

0.81

1.39

 

   4-7 hours/week

1.06

0.86

1.31

1.11

0.68

1.81

 

1.13

0.94

1.36

 

1.10

0.96

1.26

0.99

0.75

1.30

 

   >7 hours/week

1.09

0.89

1.33

1.02

0.64

1.62

0.79

1.13

0.95

1.35

0.90

1.10

0.97

1.26

0.81

0.62

1.06

0.03

Ages 19-29 years

                  

   Never/Rarely

1.00 (ref.)

  

1.00 (ref.)

   

1.00 (ref.)

   

1.00 (ref.)

  

1.00 (ref.)

   

   <1 hour/week

1.20

0.88

1.66

0.88

0.41

1.87

 

1.09

0.82

1.46

 

1.12

0.91

1.37

1.48

0.94

2.32

 

   1-3 hours/week

1.11

0.85

1.45

0.91

0.50

1.66

 

1.05

0.83

1.33

 

1.06

0.89

1.26

1.38

0.94

2.04

 

   4-7 hours/week

1.00

0.77

1.31

1.04

0.59

1.86

 

1.17

0.93

1.48

 

1.09

0.92

1.29

1.31

0.90

1.92

 

   >7 hours/week

0.99

0.77

1.27

1.04

0.59

1.86

0.99

1.14

0.91

1.42

0.00

1.06

0.90

1.25

1.15

0.79

1.66

0.91

Ages 35-39 years

                  

   Never/Rarely

1.00 (ref.)

  

1.00 (ref.)

   

1.00 (ref.)

   

1.00 (ref.)

  

1.00 (ref.)

   

   <1 hour/week

1.07

0.77

1.50

1.14

0.46

2.84

 

1.21

0.90

1.65

 

1.15

0.92

1.43

1.26

0.80

1.99

 

   1-3 hours/week

1.07

0.81

1.41

1.48

0.70

3.13

 

1.17

0.91

1.52

 

1.15

0.95

1.38

1.17

0.80

1.73

 

   4-7 hours/week

0.91

0.69

1.19

1.44

0.69

3.00

 

1.12

0.87

1.44

 

1.04

0.87

1.25

1.07

0.73

1.57

 

   >7 hours/week

0.89

0.68

1.16

1.48

0.72

3.02

0.20

1.20

0.94

1.53

0.18

1.08

0.91

1.28

0.94

0.65

1.37

0.52

Past 10 years

                  

   Never/Rarely

1.00 (ref.)

  

1.00 (ref.)

   

1.00 (ref.)

   

1.00 (ref.)

  

1.00 (ref.)

   

   <1 hour/week

1.20

0.86

1.69

0.35

0.14

0.92

 

1.24

0.94

1.64

 

1.14

0.93

1.41

1.50

0.95

2.38

 

   1-3 hours/week

1.06

0.80

1.41

1.04

0.59

1.86

 

1.00

0.79

1.27

 

1.03

0.86

1.22

1.35

0.91

2.02

 

   4-7 hours/week

1.19

0.90

1.57

0.94

0.53

1.66

 

1.11

0.88

1.40

 

1.12

0.95

1.33

1.24

0.83

1.84

 

   >7 hours/week

0.92

0.70

1.22

0.80

0.45

1.40

0.65

1.07

0.85

1.35

0.53

0.99

0.84

1.17

1.11

0.75

1.63

0.61

No. cancer cases**

1352

  

263

   

1907

   

3522

  

736

   
  1. * Relative risks adjusted for: age (continuous); race/ethnicity (white, black, Hispanic, Asian/Pacific Islander/American Indian); education level (<12 years or high school equivalent, 12 years or high school equivalent, post-high school vocational or technical training, some college, college graduate, post-graduate); smoking status (non-smoker, former, current); alcohol intake (grams/day, quintiles adjusted for total energy intake); family history of breast cancer (no, yes); age at menarche (<13, 13-14, ≥ 15 years); age at first birth (nulliparous, <20, 20-24, 25-29, 30+ years); parity (number of children: 0, 1-2, 3 or more); age at menopause (<40, 40-44, 45-49, 50-54, ≥ 55 years); menopausal hormone use (never, ever)
  2. ** Total numbers of cancer cases may vary due to missing physical activity values.
  3. † ER: estrogen receptor. Hormone receptor status limited to invasive cancers.
  4. †† p-value for heterogeneity comparing RR for >7 hours/week of physical activity: ER-positive and ER-negative tumors.
  5. §p-value for heterogeneity comparing RR for >7 hours/week of physical activity: ER-positive, ER-negative, and ER-unknown tumors.
  6. £ p-value for heterogeneity comparing RR for >7 hours/week of physical activity: invasive and in situ tumors
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BMC Cancer

ISSN: 1471-2407

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