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Table 2 Univariate analysis of clinicopathologic factors associated with disease-free survival and overall survival

From: Adjuvant concurrent chemoradiation therapy (CCRT) alone versus CCRT followed by adjuvant chemotherapy: Which is better in patients with radically resected extrahepatic biliary tract cancer?: a non-randomized, single center study

  

No. of patients (%)

P value (OS)

P value (DFS)

Age

> 60

68 (56.7)

0.506

0.849

 

≤ 60

52 (43.3)

  

Sex

M

89 (74.2)

0.321

0.443

 

F

31 (25.8)

  

T stage

T1/T2

53 (44.2)

0.679

0.645

 

T3/T4

67 (55.8)

  

N stage

N0

77 (64.2)

0.223

0.005

 

N1

43 (35.8)

  

Stage

I

40 (33.3)

0.902

0.129

 

II/III

80 (66.7)

  

Resection margin

Negative

79 (65.8)

0.811

0.700

 

Positive

41 (34.2)

  

CA 19-9

≤ 60 U/ml

57 (47.5)

0.048

0.011

 

> 60 U/mL

62 (51.7)

  

Tumor location

Proximal

59 (49.2)

0.207

0.224

 

Distal

55 (45.8)

  

Histologic grade

WD/MD

107 (89.2)

0.065

0.029

 

PD

11 (9.2)

  

Angiolymphatic invasion

Yes

38 (31.7)

0.789

0.576

 

No

62 (51.7)

  

Perineural invasion

Yes

87 (72.5)

0.419

0.098

 

No

24 (24.0)

  

Adjuvant treatment

CCRT

30 (25.0)

0.004

0.038

 

CCRT + AC

90 (75.0)

  
  1. OS, overall survival; DFS, disease-free survival; WD, well differentiated; MD, moderate differentiated; PD, poor differentiated; CCRT, concurrent chemoradiation therapy; AC, adjuvant chemotherapy.