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Table 2 Univariate analysis of clinicopathologic factors associated with disease-free survival and overall survival

From: Adjuvant concurrent chemoradiation therapy (CCRT) alone versus CCRT followed by adjuvant chemotherapy: Which is better in patients with radically resected extrahepatic biliary tract cancer?: a non-randomized, single center study

   No. of patients (%) P value (OS) P value (DFS)
Age > 60 68 (56.7) 0.506 0.849
  ≤ 60 52 (43.3)   
Sex M 89 (74.2) 0.321 0.443
  F 31 (25.8)   
T stage T1/T2 53 (44.2) 0.679 0.645
  T3/T4 67 (55.8)   
N stage N0 77 (64.2) 0.223 0.005
  N1 43 (35.8)   
Stage I 40 (33.3) 0.902 0.129
  II/III 80 (66.7)   
Resection margin Negative 79 (65.8) 0.811 0.700
  Positive 41 (34.2)   
CA 19-9 ≤ 60 U/ml 57 (47.5) 0.048 0.011
  > 60 U/mL 62 (51.7)   
Tumor location Proximal 59 (49.2) 0.207 0.224
  Distal 55 (45.8)   
Histologic grade WD/MD 107 (89.2) 0.065 0.029
  PD 11 (9.2)   
Angiolymphatic invasion Yes 38 (31.7) 0.789 0.576
  No 62 (51.7)   
Perineural invasion Yes 87 (72.5) 0.419 0.098
  No 24 (24.0)   
Adjuvant treatment CCRT 30 (25.0) 0.004 0.038
  CCRT + AC 90 (75.0)   
  1. OS, overall survival; DFS, disease-free survival; WD, well differentiated; MD, moderate differentiated; PD, poor differentiated; CCRT, concurrent chemoradiation therapy; AC, adjuvant chemotherapy.