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Table 1 Distribution of "very early" and "early" HCC, according to the different variables.

From: Early and very early hepatocellular carcinoma: when and how much do staging and choice of treatment really matter? A multi-center study

  

Very EarlyHCC (65)

EarlyHCC (465)

Variables

 

N

%

N

%

Gender

Male (M)

43

66

316

68

 

Female (F)

22

34

149

32

Age

< 60

16

24

107

23

 

60 – 70

31

48

214

46

 

> 70

18

28

144

31

Disease Aetiology

HBV

4

6

42

9

 

HCV

44

68

274

59

 

Alcohol abuse

7

11

51

11

 

Alcohol and virus

4

6

56

12

 

Mixed and others

6

9

42

9

HCC diagnosis

Incidental

6

9

116

25

 

Surveillance

58

89

326

70

 

Symptomatic

1*

2

23*

5

Alfafetoprotein

< 20 ng/ml

31

47

228

49

 

20–200 ng/ml

27

42

205

44

 

> 200 ng/ml

7

11

32

7

Bilirubin

< 2 mg/dl

62

95

398

85

 

≥2 mg/dl

3

5

67

15

Lesion number

1

65

100

344

74

 

2–3

0

0

121

26

Tumor size

≤2 cm

65

100

158

34

 

2–3 cm

0

0

202

43

 

> 3 cm

0

0

105

23

Child-Pugh class

A

65

100

331

71

 

B

0

0

134

29

CLIP score

0

61

93

243

52

 

1

4

7

167

36

 

2

0

0

47

10

 

3

0

0

8

2

Type of treatment

OLTx

3

5

11

2

 

RESECTION

8

12

75

16

 

RFTA

14

22

58

12

 

PEI

20

30

106

23

 

TACE

17

26

128

28

 

PEI + TACE

-

-

25

6

 

BSC

3

5

62

13

  1. OLTx: orthotopic liver transplantation; RFTA: radiofrequency-mediated thermal ablation;
  2. PEI: percutaneous ethanol injection; TACE: transcatheter arterial chemoembolization; BSC: best supportive care.