Transcription factor AP-1 in esophageal squamous cell carcinoma: Alterations in activity and expression during Human Papillomavirus infection

Table 4 AP-1 protein expression profile and their densitometric analysis in HPV negative and HPV positive cases of ESCC.

AP-1 Family Member Protein	HPV negative Cases (n = 61)				HPV positive Cases (n = 14)				p value
	Nil	Weak	Medium	Strong	Nil	Weak	Medium	Strong
cJun	-	5	20	36	-	-	4	10	0.6
JunB	2	8	26	25	-	1	4	9	0.64
JunD	-	7	19	35	-	-	2	12	0.41
cFos	-	-	13	48	-	-	-	14	ND
FosB	2	13	23	23	-	1	6	7	0.2
Fra-1	-	14	10	37	11	3	-	-	0.001
Fra-2	8	10	15	28	3	6	3	2	0.03

Arbitrary level of expression in Immunoblotting: strong =>50%; medium = 10-50%; Weak = 1-10%; and Nil/undetectable =< 1%. Statistical calculation was done by grouping nil & weak, medium & strong together. Yates corrected chi-square/Fishers exact test were performed.

ISSN: 1471-2407