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Table 4 AP-1 protein expression profile and their densitometric analysis in HPV negative and HPV positive cases of ESCC.

From: Transcription factor AP-1 in esophageal squamous cell carcinoma: Alterations in activity and expression during Human Papillomavirus infection

AP-1 Family Member Protein HPV negative Cases
(n = 61)
HPV positive Cases
(n = 14)
p value
  Nil Weak Medium Strong Nil Weak Medium Strong  
cJun - 5 20 36 - - 4 10 0.6
JunB 2 8 26 25 - 1 4 9 0.64
JunD - 7 19 35 - - 2 12 0.41
cFos - - 13 48 - - - 14 ND
FosB 2 13 23 23 - 1 6 7 0.2
Fra-1 - 14 10 37 11 3 - - 0.001
Fra-2 8 10 15 28 3 6 3 2 0.03
  1. Arbitrary level of expression in Immunoblotting: strong =>50%; medium = 10-50%; Weak = 1-10%; and Nil/undetectable =< 1%. Statistical calculation was done by grouping nil & weak, medium & strong together. Yates corrected chi-square/Fishers exact test were performed.