Transcription factor AP-1 in esophageal squamous cell carcinoma: Alterations in activity and expression during Human Papillomavirus infection

Table 3 Expression profile of AP-1 proteins in immunoblotting and densitometric analysis of their level of expression in normal adjacent controls and tumor tissues of ESCC.

AP-1 Family Member Protein	Normal (n = 75)				Cancer (n = 75)				p-value
	Nil	Weak	Medium	Strong	Nil	Weak	Medium	Strong
cJun	10	23	42	-	-	5	24	46	0.001
JunB	49	16	8	2	2	9	30	34	0.001
JunD	53	20	2	-	-	7	21	47	0.001
cFos	69	6	-	-	-	-	13	62	0.001
FosB	4	8	36	27	2	14	29	30	0.52
Fra-1	35	12	19	9	11	17	10	37	0.003
Fra-2	5	5	28	37	11	16	18	30	0.002

Arbitrary level of expression in Immunoblotting: strong =>50%; medium = 10-50%; Weak = 1-10%; and Nil/undetectable =< 1%. Statistical calculation was done by grouping nil & weak, medium & strong together. Yates corrected chi-square/Fishers exact test were performed.

ISSN: 1471-2407