Expression analysis of E-cadherin, Slug and GSK3β in invasive ductal carcinoma of breast

BMC Cancer

Table 2 Analysis of relationships between E-cadherin, Slug and GSK3β expression with β-catenin expression in IDCs.

Parameter	Total Cases (N)	E-Cad (Mem)			E-Cad (Cyto)			Slug (Nucl)			Gsk3β (Nucl)			Gsk3β (Cyto)
		-	+	P	-	+	P	-	+	P	-	+	P	-	+	P
	98	53	45		46	52		65	33		64	34		52	46
β-catenin (Mem.)
Positive	33	9	24	.0001*¹	12	21	.199	16	17	0.012*³	19	14	0.270	19	14	0.669
Negative	65	44	21		34	31		49	16		45	20		33	32
β-catenin (Cyto.)
Positive	42	20	22	0.309	18	24	0.543	21	21	0.005*⁴	24	18	0.198	17	25	0.070
Negative	56	33	23		28	28		44	12		40	16		35	21
β-catenin (Nucl.)
Positive	47	25	22	1.000	17	30	0.046*²	23	24	0.001*⁵	28	19	0.292	20	27	0.068
Negative	51	28	23		29	22		42	9		36	15		32	19

Abbreviations: E-cad, E-cadherin; Cyto, Cytoplasmic; Nucl, Nuclear and Mem, Membrane.*¹ β-cat (Mem) ^- /E-cad (Mem) ^- : p = 0.0001; OR = 5.59 [95% C.I = 2.21-14.1]; * ² β-cat (Nucl) ⁺ /E-cad (Cyto) ⁺ : p = 0.046; OR = 2.33 [95% CI = 1.03-5.25]; * ³ β-cat (Mem) ^- /Slug (Nucl) ⁺ : p = 0.012; OR = 3.25 [95% CI = 1.34-7.89]; * ⁴ β-cat (Cyto) ⁺ /Slug (Nucl) ⁺ : p = 0.005; OR = 3.67 [95% C.I = 1.53-8.83]; * ⁵ β-cat (Nucl) ⁺ /Slug (Nucl) ⁺ : p = 0.001; OR = 4.87 [95% C.I = 1.94-12.21].

ISSN: 1471-2407