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Table 1 Relationships between expression of E-cadherin, Slug and GSK3β in IDCs of breast: Correlation with clinicopathological parameters

From: Expression analysis of E-cadherin, Slug and GSK3β in invasive ductal carcinoma of breast

Parameter Total Cases (N) E-Cad (Mem) E-Cad (Cyto) Slug (Nucl) Gsk3β (Nucl) Gsk3β (Cyto)
   - + P - + P - + P - + P - + P
  98 53 45   46 52   65 33   64 34   52 46  
Age                 
ὄ 50 62 30 32 .148 24 38 0.06 40 22 .663 44 18 0.131 30 32 .294
>50 36 23 13   22 14   25 11   20 16   22 14  
Menopausal status                 
Pre- 35 19 16 1.00 12 23 0.091 22 13 .658 27 8 .079 19 16 1.00
Post- 63 34 29   34 29   43 20   37 26   33 30  
Tumor grade                 
T1+T2 53 24 29 .060 21 32 0.155 29 24 .01*1 29 24 .02*2 26 27 .422
T3+T4 45 29 16   25 20   36 9   35 10   26 19  
Lymphatic involvement                 
N0 36 19 17 1.00 18 18 0.679 22 14 .507 20 16 0.131 18 18 .675
N1-2 62 34 28   28 34   43 19   44 18   34 28  
Grade                 
I+II 56 27 29 .221 22 34 0.103 33 23 .087 32 24 .05*3 31 25 .684
III+IV 42 26 16   24 18   32 10   32 10   21 21  
ER                 
+ve 28 17 11 .502 13 15 1.00 15 13 .103 13 15 .019*4 17 11 .377
-ve 70 36 34   33 37   50 20   51 19   35 35  
  1. *TNM Classification on basis of AJCC classification [46]. Abbreviations: E-cad, E-cadherin; Cyto, Cytoplasmic; Nucl, Nuclear and Mem, Membrane. * 1 p = 0.01; OR = 0.191 [95% CI = 0.122-0.75]; * 2 p = 0.02; OR = 0.3 [95%CI = 0.142-0.838]; * 3 p = 0.05; OR = 0.417 [95%CI = 0.172-1.01]; * 4 p = 0.019; OR = 3.09 [95%CI= 1.24-7.09]. * p values were calculated using Fischer exact test. p < 0.05 was considered as significant and are given in the table. Analysis of relationships between E-cadherin, Slug and GSK3β expression in IDCs showed the following significant associations: E-cad (Mem) - /Slug (Nucl) + : p = 0.001; OR = 4.49 [95% C.I = 1.82-11.8]; E-cad (Cyto) + /E-cad (Mem) - : p = 0.016; OR = 2.82 [95% C.I = 1.23-6.44]; E-cad (Cyto) + /Slug (Nucl) + : p = 0.031; OR = 2.88 [95% C.I = 1.17-6.95]; GSK3β (Cyto) + /GSK3β (Nucl) + : p = 0.012; OR = 3.06 [95% CI = 1.28-7.27].