Expression analysis of E-cadherin, Slug and GSK3β in invasive ductal carcinoma of breast

BMC Cancer

Table 1 Relationships between expression of E-cadherin, Slug and GSK3β in IDCs of breast: Correlation with clinicopathological parameters

Parameter	Total Cases (N)	E-Cad (Mem)			E-Cad (Cyto)			Slug (Nucl)			Gsk3β (Nucl)			Gsk3β (Cyto)
		-	+	P	-	+	P	-	+	P	-	+	P	-	+	P
	98	53	45		46	52		65	33		64	34		52	46
Age
ὄ 50	62	30	32	.148	24	38	0.06	40	22	.663	44	18	0.131	30	32	.294
>50	36	23	13		22	14		25	11		20	16		22	14
Menopausal status
Pre-	35	19	16	1.00	12	23	0.091	22	13	.658	27	8	.079	19	16	1.00
Post-	63	34	29		34	29		43	20		37	26		33	30
Tumor grade
T₁+T₂	53	24	29	.060	21	32	0.155	29	24	.01*¹	29	24	.02*²	26	27	.422
T₃+T₄	45	29	16		25	20		36	9		35	10		26	19
Lymphatic involvement
N₀	36	19	17	1.00	18	18	0.679	22	14	.507	20	16	0.131	18	18	.675
N_1-2	62	34	28		28	34		43	19		44	18		34	28
Grade
I+II	56	27	29	.221	22	34	0.103	33	23	.087	32	24	.05*³	31	25	.684
III+IV	42	26	16		24	18		32	10		32	10		21	21
ER
+ve	28	17	11	.502	13	15	1.00	15	13	.103	13	15	.019*⁴	17	11	.377
-ve	70	36	34		33	37		50	20		51	19		35	35

*TNM Classification on basis of AJCC classification [46]. Abbreviations: E-cad, E-cadherin; Cyto, Cytoplasmic; Nucl, Nuclear and Mem, Membrane. * ¹ p = 0.01; OR = 0.191 [95% CI = 0.122-0.75]; * ² p = 0.02; OR = 0.3 [95%CI = 0.142-0.838]; * ³ p = 0.05; OR = 0.417 [95%CI = 0.172-1.01]; * ⁴ p = 0.019; OR = 3.09 [95%CI= 1.24-7.09]. * p values were calculated using Fischer exact test. p < 0.05 was considered as significant and are given in the table. Analysis of relationships between E-cadherin, Slug and GSK3β expression in IDCs showed the following significant associations: E-cad (Mem) ^- /Slug (Nucl) ⁺ : p = 0.001; OR = 4.49 [95% C.I = 1.82-11.8]; E-cad (Cyto) ⁺ /E-cad (Mem) ^- : p = 0.016; OR = 2.82 [95% C.I = 1.23-6.44]; E-cad (Cyto) ⁺ /Slug (Nucl) ⁺ : p = 0.031; OR = 2.88 [95% C.I = 1.17-6.95]; GSK3β (Cyto) ⁺ /GSK3β (Nucl) ⁺ : p = 0.012; OR = 3.06 [95% CI = 1.28-7.27].

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