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Table 3 Multivariate logistic regression analysis of clinical parameters associated with p53 over-expression in HCC.

From: CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection

Clinicopathological parameters p53 over-expression in HCC Unadjusted OR
(95% CI)a
Adjusted OR
(95% CI)b
  Positive
(n = 25)
Negative
(n = 129)
  
Age (years) 52.5 ± 14.8 56.8 ± 15.0 0.985 (0.958 - 1.013) 0.995 (0.942 - 1.050)
Sex (male) 23 (92.0%) 91 (70.5%) 4.802 (1.019 - 31.022)c 10.217 (0.861 - 121.307)
HBsAg (positive) 22 (88.0%) 82 (63.6%) 4.203 (1.110 - 18.673)d 1.490 (0.130 - 17.10)
Anti-HCV (positive) 4 (16.0%) 38 (29.5%) 0.456 (0.123 - 1.537) 0.791 (0.074 - 8.490)
Cirrhosis (yes) 14 (56.0%) 59 (45.7%) 1.510 (0.590 - 3.893) 1.639 (0.396 - 6.783)
Alcoholism (yes) 5 (20.0%) 38 (29.5%) 0.599 (0.182 - 1.857) 0.269 (0.052 - 1.390)
Creatinine (mg/dL) 1.0 ± 0.2 1.2 ± 1.0 0.614 (0.193 - 1.954) 0.106 (0.003 - 4.139)
Tumor characteristics     
   Microvascular invasion (yes) 10 (40.0%) 36 (27.9%) 1.722 (0.647 - 4.547) 1.658 (0.249 - 11.043)
   Edmondson's grading (> 2) 15 (60.0%) 93 (72.1%) 0.581 (0.220 - 1.545) 1.800 (0.404 - 8.019)
   Encapsulation (yes) 18 (72.0%) 98 (76.0%) 0.813 (0.286 - 2.381) 0.600 (0.097 - 3.691)
   Tumor number (> 2) 4 (16.0%) 26 (20.2%) 0.755 (0.200 - 2.609) 0.566 (0.080 - 4.008)
   Microsatellites (yes) 3 (12.0%) 24 (18.6%) 0.597 (0.130 - 2.349) 2.520 (0.213 - 29.798)
   Tumor size (Diameter, cm) 9.3 ± 9.5 6.9 ± 4.7 1.008 (0.920 - 1.104) 0.781 (0.590 - 1.034)
   Portal Vein Thrombosis (yes) 6 (24.0%) 53 (41.1%) 0.453 (0.150 - 1.308) 4.645 (0.368 - 58.611)
   Alpha-fetoprotein (100 ng/mL) 10.2 ± 27.5 62.0 ± 323.9 0.995 (0.982 - 1.008) 0.991 (0.967 - 1.016)
Liver Function     
   Albumin (g/dL) 3.7 ± 0.7 3.8 ± 0.7 0.860 (0.436 - 1.699) 2.560 (0.644 - 10.184)
   Bilirubin (mg/dL) 1.2 ± 0.8 1.3 ± 1.8 0.950 (0.688 - 1.310) 0.591 (0.273 - 1.283)
   Prothrombin time (sec) 12.5 ± 1.9 12.4 ± 1.5 1.049 (0.798 - 1.379) 1.146 (0.752 - 1.745)
   Ascites (yes) 3 (12.0%) 11 (8.5%) 1.463 (0.296 - 6.358) 4.545 (0.613 - 33.665)
Liver necroinflammation     
   AST (U/L) 132.0 ± 210.7 88.7 ± 89.0 1.002 (0.999 - 1.006) 1.017 (1.005 - 1.030)
   ALT (U/L) 90.4 ± 127.8 74.1 ± 91.0 1.001 (0.996 - 1.005) 0.985 (0.972 - 0.999)
   CD133 expression 2 (8.0%) 22 (17.1%) 0.423 (0.064 - 2.064) 0.537 (0.055 - 5.202)
  1. aUnadjusted odds ratios were calculated using regression analysis for parametric data and chi-square test for categorical data.
  2. bOdds ratios adjusted for all other variables in this table;.
  3. cP = 0.046; dP = 0.031