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Table 3 Multivariate logistic regression analysis of clinical parameters associated with p53 over-expression in HCC.

From: CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection

Clinicopathological parameters

p53 over-expression in HCC

Unadjusted OR

(95% CI)a

Adjusted OR

(95% CI)b

 

Positive

(n = 25)

Negative

(n = 129)

  

Age (years)

52.5 ± 14.8

56.8 ± 15.0

0.985 (0.958 - 1.013)

0.995 (0.942 - 1.050)

Sex (male)

23 (92.0%)

91 (70.5%)

4.802 (1.019 - 31.022)c

10.217 (0.861 - 121.307)

HBsAg (positive)

22 (88.0%)

82 (63.6%)

4.203 (1.110 - 18.673)d

1.490 (0.130 - 17.10)

Anti-HCV (positive)

4 (16.0%)

38 (29.5%)

0.456 (0.123 - 1.537)

0.791 (0.074 - 8.490)

Cirrhosis (yes)

14 (56.0%)

59 (45.7%)

1.510 (0.590 - 3.893)

1.639 (0.396 - 6.783)

Alcoholism (yes)

5 (20.0%)

38 (29.5%)

0.599 (0.182 - 1.857)

0.269 (0.052 - 1.390)

Creatinine (mg/dL)

1.0 ± 0.2

1.2 ± 1.0

0.614 (0.193 - 1.954)

0.106 (0.003 - 4.139)

Tumor characteristics

    

   Microvascular invasion (yes)

10 (40.0%)

36 (27.9%)

1.722 (0.647 - 4.547)

1.658 (0.249 - 11.043)

   Edmondson's grading (> 2)

15 (60.0%)

93 (72.1%)

0.581 (0.220 - 1.545)

1.800 (0.404 - 8.019)

   Encapsulation (yes)

18 (72.0%)

98 (76.0%)

0.813 (0.286 - 2.381)

0.600 (0.097 - 3.691)

   Tumor number (> 2)

4 (16.0%)

26 (20.2%)

0.755 (0.200 - 2.609)

0.566 (0.080 - 4.008)

   Microsatellites (yes)

3 (12.0%)

24 (18.6%)

0.597 (0.130 - 2.349)

2.520 (0.213 - 29.798)

   Tumor size (Diameter, cm)

9.3 ± 9.5

6.9 ± 4.7

1.008 (0.920 - 1.104)

0.781 (0.590 - 1.034)

   Portal Vein Thrombosis (yes)

6 (24.0%)

53 (41.1%)

0.453 (0.150 - 1.308)

4.645 (0.368 - 58.611)

   Alpha-fetoprotein (100 ng/mL)

10.2 ± 27.5

62.0 ± 323.9

0.995 (0.982 - 1.008)

0.991 (0.967 - 1.016)

Liver Function

    

   Albumin (g/dL)

3.7 ± 0.7

3.8 ± 0.7

0.860 (0.436 - 1.699)

2.560 (0.644 - 10.184)

   Bilirubin (mg/dL)

1.2 ± 0.8

1.3 ± 1.8

0.950 (0.688 - 1.310)

0.591 (0.273 - 1.283)

   Prothrombin time (sec)

12.5 ± 1.9

12.4 ± 1.5

1.049 (0.798 - 1.379)

1.146 (0.752 - 1.745)

   Ascites (yes)

3 (12.0%)

11 (8.5%)

1.463 (0.296 - 6.358)

4.545 (0.613 - 33.665)

Liver necroinflammation

    

   AST (U/L)

132.0 ± 210.7

88.7 ± 89.0

1.002 (0.999 - 1.006)

1.017 (1.005 - 1.030)

   ALT (U/L)

90.4 ± 127.8

74.1 ± 91.0

1.001 (0.996 - 1.005)

0.985 (0.972 - 0.999)

   CD133 expression

2 (8.0%)

22 (17.1%)

0.423 (0.064 - 2.064)

0.537 (0.055 - 5.202)

  1. aUnadjusted odds ratios were calculated using regression analysis for parametric data and chi-square test for categorical data.
  2. bOdds ratios adjusted for all other variables in this table;.
  3. cP = 0.046; dP = 0.031