| | |
DFS
| |
OS
| |
|---|
| | |
HR (95% CI)
|
P
|
HR (95% CI)
|
P
|
|---|
|
TIMP-1
|
Continuous variable
|
1.18 (0.87-1.59)
|
0.28
|
1.29 (0.87-1.91)
|
0.20
|
| |
High vs. low
|
1.23 (0.87-1.73)
|
0.25
|
1.64 (1.02-2.65)
|
0.04
|
|
Age
|
41-55 years vs. ≤ 40 years
|
0.60 (0.43-0.85)
|
0.004
|
0.53 (0.33-0.84)
|
0.007
|
|
Tumor size
|
Stage 2 (> 2 cm) vs. stage 1 (≤ 2 cm)
|
1.59 (1.07-2.38)
|
0.02
|
2.34 (1.31-4.20)
|
0.01
|
| |
Stage 3 (>5 cm or chest wall/skin involvement) vs. stage 1 (≤ 2 cm)
|
1.92 (1.15-3.22)
| |
1.97 (0.92-4.20)
| |
|
Grade
|
Unknown vs. poor
|
0.83 (0.55-1.25)
|
0.24
|
1.05 (0.60-1.84)
|
0.62
|
| |
Well/moderate vs. poor
|
0.68 (0.43-1.10)
| |
0.74 (0.38-1.46)
| |
- * Analyses stratified for hormone receptor status, nodal status and RT on the axilla. The results for age, tumor size and grade are from the base model not including TIMP-1. TIMP-1 was added separately as a continuous variable and then as a dichotomized one. The coefficients for age, tumor size and grade were similar with TIMP-1 included.
