| | |
DFS
| |
OS
| |
|---|
| | |
HR (95% CI)
|
P
|
HR (95% CI)
|
P
|
|---|
|
TIMP-1
|
Continuous variable
|
1.75 (1.00-3.07)
|
0.05
|
4.19 (1.67-10.51)
|
0.002
|
| |
High vs. low
|
1.48 (0.84-2.61)
|
0.17
|
2.59 (1.14-5.88)
|
0.02
|
|
Age
|
41-55 years vs. ≤ 40 years
|
0.68 (0.37-1.25)
|
0.22
|
0.80 (0.37-1.72)
|
0.57
|
|
Tumor size
|
Stage 2 (> 2 cm) vs. stage 1 (≤ 2 cm)
|
2.13 (0.91-4.98)
|
0.13
|
3.63 (0.82-16.13)
|
0.14
|
| |
Stage 3 (>5 cm or chest wall/skin involvement) vs. stage 1 (≤ 2 cm)
|
2.31 (0.87-6.11)
| |
2.77 (0.54-14.14)
| |
|
Grade
|
Unknown vs. poor
|
0.90 (0.43-1.92)
|
0.88
|
0.16 (0.02-1.21)
|
0.06
|
| |
Well/moderate vs. poor
|
0.82 (0.35-1.88)
| |
1.11 (0.39-3.15)
| |
- * Analyses stratified for hormone receptor status, nodal status and RT on the axilla. The results for age, tumor size and grade are from the base model not including TIMP-1. TIMP-1 was added separately as a continuous variable and then as a dichotomized one. The coefficients for age, tumor size and grade were similar with TIMP-1 included.
