Table 1 Patient and tumor characteristics and comparisons of patient groups
Characteristic | All patients N (%) | CMF-treated patients N (%) | Anthracycline-treated patients N (%) | Untreated patients N (%) | P1 |
|---|---|---|---|---|---|
Age | Â | Â | Â | Â | Â |
≤ 40 years | 164 (31) | 110 (34) | 28 (28) | 26 (25) | 0.212 |
41-55 years | 361 (69) | 214 (66) | 71 (72) | 76 (75) | Â |
Involved lymph nodes | Â | Â | Â | Â | Â |
1-3 | 292 (56) | 217 (67) | 47 (47) | 28 (27) | <0.0012 |
>3 | 233 (44) | 107 (33) | 52 (53) | 74 (73) | Â |
Steroid hormone rec. status | Â | Â | Â | Â | Â |
Positive | 432 (82) | 269 (83) | 76 (77) | 87 (85) | 0.242 |
Negative | 93 (18) | 55 (17) | 23 (23) | 15 (15) | Â |
Tumor size | Â | Â | Â | Â | Â |
pT1 | 175 (33) | 131 (40) | 21 (21) | 23 (23) | <0.0012 |
pT2 | 270 (51) | 147 (45) | 58 (59) | 65 (64) | Â |
pT3+4 | 80 (15) | 46 (14) | 20 (20) | 14 (14) | Â |
Grade | Â | Â | Â | Â | Â |
Well/moderate | 103 (20) | 65 (20) | 21 (21) | 17 (17) | 0.332 |
Poor | 291 (55) | 174 (54) | 61 (62) | 56 (55) | Â |
Unknown | 131 (25) | 85 (26) | 17 (17) | 29 (28) | Â |
Primary treatment | Â | Â | Â | Â | Â |
Lumpectomy | 212 (40) | 169 (52) | 4 (4) | 39 (38) | <0.0012 |
Mastectomy | 313 (60) | 155 (48) | 95 (96) | 63 (62) | Â |
Events 3 | Â | Â | Â | Â | Â |
Recurrences (disease failure) | 268 | 140 | 58 | 70 | Â |
Deaths | 149 | 75 | 32 | 42 | Â |
TIMP-1 (median, range) | 12.5 (0- 113) | 12.0 (0- 106) | 13.5 (0-51.2) | 13.8 (0- 113) | 0.204 |