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Table 4 Clinical characteristics and results of immunohistochemistry for ASCL1, DKK1 and TPH1

From: Identification of Achaete-scute complex-like 1 (ASCL1) target genes and evaluation of DKK1 and TPH1 expression in pancreatic endocrine tumours

Tumour no

Gender

Age at

diagnosis

WHO

Syndrome

ASCL1

DKK1

TPH1

1

M

53

2

NF

High

Low

Heterogeneous

2

F

47

1

NF/MEN 1

High

Low

Low

3

M

50

2

IN

High

Low

 

4

F

86

1

IN

High

Low

 

5

F

40

1

GA

High (p)

Low (p)

Heterogeneous

6

M

44

2

GL

High

Low

Heterogeneous

7

M

51

2

NF

Low

High

 

8

F

46

2

NF

Low

High

 

9

F

34

2

NF

Low

High

 

10

M

62

1

NF/MEN 1

Low

High (p)

Heterogeneous (p)

11

M

53

2

NF/MEN 1

Low

High

 

12

M

48

2

NF/MEN 1

Low

N/D

Heterogeneous

13

M

47

2

IN

Low

High

Heterogeneous

14

M

19

1

IN/MEN 1

Low

High

Heterogeneous

15*

M

53

2

GL

Low

High

High

16

M

72

2

GA

Low

High

 

17

M

50

3

NF

High

High

 

18

F

44

2

NF

High

High

 

19

F

23

3

NF

High

High

 

20

M

57

1

NF/MEN 1

High

High

High

21

F

44

1

NF

Low

Low

Heterogeneous

22

M

22

1

NF/MEN 1

Low

Low

High/Heterogeneous

23

M

64

1

IN

Low (p)

Low

 
  1. Immunoreactivity was graded as Low, High or Heterogeneous. ASCL1 immunoreactivity has been determined previously (8) were grading +, ++ is here denoted Low and +++ denoted High. N/D, not determined; *, liver metastasis; p, in Figure 6. WHO classifications: 1, well-differentiated endocrine tumour, 2, well-differentiated endocrine carcinoma, 3, poorly differentiated endocrine carcinoma. NF, non-functioning; MEN 1, Multiple Endocrine Neoplasia 1; IN, insulinoma; GA, gastrinoma; GL, glucagonoma