Clinical significance of altered nm23-H1, EGFR, RB and p53 expression in bilharzial bladder cancer

BMC Cancer

Table 3 The correlation between aberrant expression level of the studied markers and the clinicopathological features of the patients

Parameter	nm23-H1 IHC(25)	nm23-H1 RNA (19)	EGFR IHC(39)	EGFR RNA (32)	Rb IHC(34)	P53 IHC(21)
*Age(mean ± SD)*	50.2 ± 11	54.o ± 8.6	51.7 ± 11	48.5 ± 10.2	49.5 ± 11.4	53.9 ± 11.3
p value	0.41	0.63	0.73	0. 41	0.144	0.175
*Sex*
Male (42)	19	13	28	25	22	17
Female (17)	6	4	11	7	12	4
p value	0.48	0.42	0.88	0.62	0.2	0.22
*Pathology:*
SCC	14	9	16	9	16	7
TCC	10	8	20	20	16	12
AC	1	2	3	3	2	2
P value	0.536	0.661	0.21	0.365	0.85	0.36
*Grade:*
I	1	2	3	3	4	0
II	17	15	25	20	22	16
III	7	2	11	9	8	5
P value	0.916	0.713	1.0	0.785	0.71	0.224
*Stage:*
p3a	15	4	26	17	25	17
p3b	9	10	7	9	6	2
p4	1	5	6	6	3	2
P value	0.13	*0.02*	*0.003*	*0.01*	*0.023*	*0.004*
*Lymp nodes:*
Positive	9	6	8	4	4	6
Negative	16	13	31	28	30	15
P value	*<0.0001*	*<0.0001*	0.31	0.431	0.216	*0.02*
*Recurrence:*
Negative	16	15	26	24	23	13
Positive	9	4	13	8	11	8
P value	0.43	0.51	*0.06*	*0.003*	0.72	0.347
*Metastasis:*
Negative	20	15	31	23	30	13
Positiv e	5	4	8	9	4	8
*P value*	0.75	0.51	0.78	0.511	*0.026*	*<0.0001*

SCC = Squamous Cell Carcinoma; TCC = Transitional Cell Carcinoma; Adeno = Adenocarcinoma

ISSN: 1471-2407