Figure 5

Efficacy of A-928605 in the SK-N-FI neuroblastoma xenograft as a renal subcapsule model. A, A-928605 inhibits proliferation of SK-N-FI cells in vitro. B-D, Beginning on day 14 post tumor cell injection, mice were dosed intraperitoneally with A-928605 at 37.5 mg/kg, b.i.d. for 14 days. B, Representative photograph taken of the tumor bearing and contralateral kidneys prior to the initiation of dosing on day 14 post tumor cell injection, indicating a tumor weight of 0.07 g. C, Representative photograph taken of the tumor bearing and contralateral kidneys at the end of the dosing schedule (day 28). D, At the end of the dosing schedule, the %T/C (A-928605 vs. vehicle) was 58 (P < 0.001).