Figure 1

Chemical structure and activity of A-928605. A, The chemical name of A-928605 is 3-(2-(2-chlorobenzyl)-1 H-benzo [d]imidazol-5-yl)-1-((1 r, 4 r)-4-morpholinocyclohexyl)-1 H-pyrazolo [3,4-d]pyrimidin-4-amine. B, Kinome profile analysis of A-928605 on 156 unique kinases. Heat map colors correspond to the relative Ki against each kinase, where Ki greater than 1,000 nM are colored green, near 100 nM are yellow and Ki of roughly 10 nM are shaded red.