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Table 6 Literature review

From: Concurrent intra-arterial carboplatin administration and radiation therapy for the treatment of advanced head and neck squamous cell carcinoma: short term results

Author Protocol Response Toxicity Overall survival Disease free survival
Robbins KT, et al. (2000) Cisplatin 150 mg/m2 week × 4 + RT 68-72 Gy CR 80% T
CR 61 N
89 pts. grade III-IV; 6 grade V 38.8% 5-yrs 53.6% 5 yrs
Regine WF, et al. (2001) Cisplatin 150 mg/m2 week × 2 + RT 78-82 Gy CR 88% T
CR 85% N
69% grade III
7% grade IV
57% 2 yrs 63% 2 yrs
Robbins KT, et al. (2005) Cisplatin 150 mg/m2 week × 4 + RT 70 Gy CR 85% T
CR 88% N
44% grade III
39% grade IV
3% grade V
63% 2 yrs 46% 2 yrs
Rabbani A, et al. (2007) Cisplatin 150 mg/m2 week × 4 + RT 70 Gy   72% grade III, IV;
6% grade V
57% 4 yrs 65% 4 yrs
Present study Carboplatin 350 mg/m2 2 weeks × 4 + RT 66-74 Gy PTVI - 50-60 Gy PTVII CR 96% 30% grade III, IV 75% 2 yrs 69% 2 yrs