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Table 5 Non-haematological acute toxicity (NCI-CTCAE v3.0) *worst toxicity observed

From: Concurrent intra-arterial carboplatin administration and radiation therapy for the treatment of advanced head and neck squamous cell carcinoma: short term results

  Grade 1
(erithema)
Grade 2
(ulcers or pseudomembranes)
Grade 3
(confluent ulcers)
Grade 4
(necrosis)
Stomatitis* 15/56
(27%)
12/56
(21%)
4/56
(7%)
1/56
(2%)
  Grade 1
(symptomatic, regular food intake)
Grade 2
(impaired swallowing; i.v. fluids)
Grade 3
(enteral/parenteral nutrition)
Grade 4
(life-treatening consequences)
Dysphagia* 20/56
(36%)
10/56
(18%)
4/56
(7%)
0/56
-
  Grade 1
(light erithema or desquamation)
Grade 2
(moderate erithema or desquamation with oedema)
Grade 3
(erithema or desquamation with induced bleeding)
Grade 4
(necrosis with spontaneous bleeding)
Dermatitis* 14/56
(25%)
3/56
(5%)
3/56
(5%)
0/56
-
  Grade 1
(asymptomatic)
Grade 2
(symptomatic without respiratory distress)
Grade 3
(stridor, respiratory distress)
Grade 4
(severe compromission, tracheotomy)
Laryngeal oedema* 10/56
(18%)
0/56
-
0/56
-
2/56
(3%)
  Grade 1
(light)
Grade 2
(moderate)
Grade 3
(severe)
Grade 4
(disabling)
Pain* 10/56
(18%)
5/56
(9%)
0/56
-
0/56
-
  Grade 1
(flushing, or transient rash, fever < 38°)
Grade 2
(flushing, rash or orticaria, fever = 38°)
Grade 3
(bronchospasm with or without orticaria)
Grade 4
(anaphylaxis)
Allergic reactions* 1/56
(2%)
2/56
(3%)
0/56
-
0/56
-
  Grade 1
(loss of appetite)
Grade 2
(lower caloric intake without weight loss)
Grade 3
(weight loss requiring enteral/parenteral nutrition)
Grade 4
(life-threatening denutrition)
Nausea* 13/56
(23%)
0/56
-
0/56
-
0/56
-
  Grade 1
(no treatment required)
Grade 2
(necessity of brief liquid i.v infusion)
Grade 3
(necessity of continuative treatment > 24 h)
Grade 4
(shock)
Hypotension* 1/56
(2%)
2/56
(3%)
0/56
-
0/56
-
  Grade 1 Grade 2   
Alopecia* 2/56
(3%)
0/56
-