Table 2 Side effects of the combined radio-chemotherapy with TMZ and PEG-Dox.
Treatment related toxicity ** | |||
|---|---|---|---|
Common toxicity criteria (NCI CTC Version 3.0) | |||
RNOP-09 Grade 3 | RNOP-09 Grade 4* | EORTC/NCI-C Grade 3+4 | |
N (%) | N (%) | N (%) | |
Gastrointestinal | |||
Vomitus/nausea | 4 (6.3) | 0 (0.0) | 6 (2) |
Stomatitis | 2 (3.2) | 0 (0.0) | not reported |
Gastritis | 2 (3.2) | 0 (0.0) | not reported |
Diarrhea | 3 (4.8) | 0 (0.0) | not reported |
Skin | |||
PPED/rash | 4 (6.3) | 0 (0.0) | 9 (3) |
Herpes simplex infection | 2 (3.2) | 0 (0.0) | not reported |
Edema | 2 (3.2) | 0 (0.0) | not reported |
Anaphylaxis | 0 (0.0) | 1 (1.5) | not reported |
Infection | |||
Pneumonia | 8 (12.7) | 1 (1.5) | not reported |
Wound infection | 1 (1.5) | 0 (0.0) | not reported |
not specified | 9 (14.2) | 0 (0.0) | 20 (7) |
Blood/bone marrow | |||
Leukopenia | 9 (14.3) | 3 (4.7) | 20 (7.0) |
Lymphopenia | 6 (9.5) | 27 (43.9) | not reported |
Thrombopenia | 4 (6.3) | 3 (4.7) | 33 (12.0) |
Anemia | 0 (0.0) | 2 (3.2) | 4 (1.0) |
Cardiac and vascular toxicity | |||
Cardiac toxicity | 0 (0.0) | 0 (0.0) | not reported |
Deep vein thrombosis | 2 (3.2) | 0 (0.0) | not reported |
Pulmonary embolism | 0 (0.0) | 1 (1.5) | not reported |