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Table 2 Side effects of the combined radio-chemotherapy with TMZ and PEG-Dox.

From: RNOP-09: Pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma - a phase II study

Treatment related toxicity **
  Common toxicity criteria (NCI CTC Version 3.0)
  RNOP-09
Grade 3
RNOP-09
Grade 4*
EORTC/NCI-C
Grade 3+4
  N (%) N (%) N (%)
Gastrointestinal    
   Vomitus/nausea 4 (6.3) 0 (0.0) 6 (2)
   Stomatitis 2 (3.2) 0 (0.0) not reported
   Gastritis 2 (3.2) 0 (0.0) not reported
   Diarrhea 3 (4.8) 0 (0.0) not reported
Skin    
   PPED/rash 4 (6.3) 0 (0.0) 9 (3)
   Herpes simplex infection 2 (3.2) 0 (0.0) not reported
   Edema 2 (3.2) 0 (0.0) not reported
   Anaphylaxis 0 (0.0) 1 (1.5) not reported
Infection    
   Pneumonia 8 (12.7) 1 (1.5) not reported
   Wound infection 1 (1.5) 0 (0.0) not reported
   not specified 9 (14.2) 0 (0.0) 20 (7)
Blood/bone marrow    
   Leukopenia 9 (14.3) 3 (4.7) 20 (7.0)
   Lymphopenia 6 (9.5) 27 (43.9) not reported
   Thrombopenia 4 (6.3) 3 (4.7) 33 (12.0)
   Anemia 0 (0.0) 2 (3.2) 4 (1.0)
Cardiac and vascular toxicity    
   Cardiac toxicity 0 (0.0) 0 (0.0) not reported
   Deep vein thrombosis 2 (3.2) 0 (0.0) not reported
   Pulmonary embolism 0 (0.0) 1 (1.5) not reported
  1. * Two additional patients died, one due to pulmonary embolism and une due to unclear decline in general condition (CTC grade 5).
  2. ** Side effects are listed irrespective if they were related to the therapy.