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Table 1 Patients characteristics and global results for FISH/CISH EGFR GCN analysis and clinical outcome.

From: Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis

  Total Population EGFR FISH GCN
≥ 2.6
EGFR FISH GCN
< 2.6
P EGFR CISH GCN
= 2.12
EGFR CISH GCN
< 2.12
p
Number (%) 44 15 (40) 22 (60)   28 (64) 16 (36)  
Sex (%)        
Male 23 (52) 10 (67) 13 (60)   15 (53) 9 (56)  
Female 21 (48) 5 (33) 9 (40)   13 (47) 7 (44)  
Median age (range)        
  66 (39–78) 66 (39–78) 66 (39–78)   65 (39–78) 66 (40–78)  
Previous lines of Chemotherapy (%)        
1 14 (32) 5 (33) 8 (36)   8 (29) 6 (37)  
> 2 30 (68) 10 (67) 14 (64)   20 (71) 10 (63)  
Response Rate (%)        
Complete Remission 0 (0) 0 (0) 0 (0)   0 (0) 0 (0)  
Partial Remission 11 (25) 9 (60) 2 (9) 0.002 10 (36) 1 (6) 0.03
Stable Disease 12 (27) 5 (33) 8 (32)   10 (36) 2 (13)  
Progressive Disease 21 (48) 1 (7) 13 (59) 0.001 8 (30) 13 (81) 0.01
Not assessable 0 (0) 0 (0) 0 (0)   0 (0) 0 (0)  
Survival (Months)        
Time to Progression 3.6 7.7 2.9 0.04 6.4 3.1 0.02
Overall Survival 10.6 16 9.5   10.6 10.3  
  1. Only statistically significant p values have been included.