Figure 4From: Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis Receiver operating characteristics (ROC) analysis based on mean CISH EGFR gene copy number with response to cetuximab therapy as end point. In this model sensitivity was 51.5% (95% CI 33.6–69.2) and specificity was 100% (95% CI 69–100). AUC was 0.77, p = 0.002.Back to article page