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Figure 4 | BMC Cancer

Figure 4

From: Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma

Figure 4

Migration of glioma cells following MGP knockdown in a wound-healing assay. (a) Quantification of cell migration: U373fast, H4 and U343MG cells with blocked MGP expression exhibited reduced migration as compared to control cells transfected with non-silencing siRNA (set at 100%). All differences between MGP siRNA and cells transfected with control siRNA are significant (p < 0.01 = ** or p < 0.001 = ***). b-g: Representative monolayer wound healing assay using H4 cells. For better illustration of differences in migration activity, the initial borders of scratch areas are labeled. H4 cells after MGP knockdown (right panels, e, f, g) showed reduced migration into central scratch areas as compared to the control cells, transfected with non-silencing siRNA (left panels, b, c, d).

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