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Table 6 Genes found to correlate in multivariate linear regression analysis using forward selection: coefficients for each gene included in the model by drug or combination tested.

From: Resistance gene expression determines the in vitro chemosensitivity of non-small cell lung cancer (NSCLC)

 

Unstandardized

Standardized

t

Collinearity Statistics

Gene

B

Std. Error

Beta

Lower Bound

B

Std. Error

Cisplatin

      

(Constant)

403.123

33.393

 

12.072

  

GTF2H2

64.781

16.558

0.573

3.912

0.129

7.725

IAP2

-153.15

16.813

-2.122

-9.109

0.051

19.571

MRP5

71.075

8.946

0.799

7.945

0.274

3.651

P53

-91.289

11.062

-0.63

-8.252

0.476

2.101

ATM kinase

105.764

14.77

1.494

7.161

0.064

15.71

FPGS

30.449

9.411

0.391

3.235

0.19

5.263

mTOR

-14.902

14.509

-0.146

-1.027

0.137

7.273

TS

42.031

7.318

0.584

5.744

0.269

3.724

MCJ

92.954

14.616

0.908

6.36

0.136

7.355

BID

-49.393

12.785

-0.402

-3.863

0.256

3.9

Topo I

-72.192

17.437

-0.688

-4.14

0.1

9.957

Mcl-1

57.031

12.755

0.69

4.471

0.116

8.597

HER2

-12.172

5.364

-0.179

-2.269

0.448

2.233

MVP

-30.265

13.535

-0.197

-2.236

0.357

2.805

Gemcitabine

      

(Constant)

338.553

35.306

 

9.589

  

MRP4

-28.047

16.241

-0.277

-1.727

1

1

Docetaxel

      

(Constant)

778.346

103.411

 

7.527

  

MRP5

62.715

14.617

0.623

4.291

0.757

1.322

GSTÏ€

-77.649

24.429

-0.461

-3.179

0.76

1.316

IGFBP2

-25.582

12.653

-0.265

-2.022

0.933

1.072

IGFBP1

28.488

10.056

0.411

2.833

0.76

1.316

MRP8

-22.098

9.513

-0.333

-2.323

0.777

1.287

Cisplatin with Gemcitabine

      

(Constant)

350.892

41.063

 

8.545

  

BAX

51.989

11.961

0.273

4.346

0.094

10.64

HER3

-10.321

4.863

-0.098

-2.122

0.172

5.813

MRP3

-19.569

1.948

-0.371

-10.044

0.272

3.681

AKT

-150.08

7.205

-1.064

-20.831

0.142

7.063

MRP8

26.222

2.484

0.45

10.556

0.203

4.915

MRP5

43.708

3.634

0.474

12.026

0.238

4.209

BCL-x(L)

178.422

11.378

1.177

15.682

0.066

15.23

EGFR

-46.006

4.356

-0.47

-10.562

0.187

5.353

hENT2

32.558

4.365

0.427

7.458

0.113

8.855

XRCC5

90.76

6.702

0.547

13.543

0.227

4.412

IGFBP1

-5.027

2.315

-0.086

-2.171

0.235

4.26

cN II

-73.932

9.164

-0.562

-8.067

0.076

13.146

HPRT

49.176

4.955

0.715

9.925

0.071

14.029

RRM1

-69.228

7.483

-0.63

-9.251

0.08

12.527

P16

7.663

2.017

0.146

3.798

0.251

3.989

TAP2

-43.744

6.008

-0.284

-7.281

0.243

4.115

MGMT

45.697

6.513

0.377

7.016

0.128

7.799

ATP7B

-7.418

2.019

-0.14

-3.675

0.255

3.928

KI67

-8.882

2.763

-0.161

-3.215

0.147

6.807

TOPO IIa

-6.788

1.708

-0.137

-3.973

0.311

3.218

BCRP

13.738

3.335

0.191

4.12

0.172

5.8

VEGF

12.683

5.573

0.098

2.276

0.199

5.034

Cisplatin with Docetaxel

      

(Constant)

178.403

46.289

 

3.854

  

APAF1

38.159

5.752

0.855

6.635

0.345

2.899

MLH1

-63.725

6.467

-1.339

-9.854

0.31

3.223

PTEN

-20.681

3.038

-0.689

-6.808

0.56

1.787

GSTÏ€

25.097

10.451

0.224

2.401

0.657

1.523

ATP7B

10.975

4.529

0.332

2.423

0.306

3.269

BCL-x(L)

24.707

11.05

0.25

2.236

0.459

2.177