Expression of the glioma-associated oncogene homolog (GLI) 1in human breast cancer is associated with unfavourable overall survival

Table 4 Univariate analysis of factors regarding overall survival (OS) and recurrence-free survival (RFS)

Variable	Categorization	Tumour-related death (OS)			Tumour recurrence (RFS)
		n	events	P ^b	n	events	P ^b
*Clinicopathological data:*
Tumour stage^a
	low (pT 0–1)	58	10	0.001	56	12	0.000
	high (pT 2–4)	128	54		123	64
Lymph node status
	negative (pN 0)	78	12	0.000	77	14	0.000
	positive (pN 1–3)	101	46		98	57
Histologic grade
	low (G 1–2)	102	26	0.001	97	30	0.000
	high (G 3)	83	38		81	45
Multifocality
	unifocal tumour	162	53	0.164	157	65	0.453
	multifocal tumour	24	11		22	11
Histologic type
	ductal	152	51	0.614	149	65	0.562
	lobular	14	7		12	5
	other	18	6		16	5
*Immunohistochemistry (IHC):*
Oestrogen receptor status
	negative (IRS 0–2)	84	35	0.006	83	39	0.055
	positive (IRS 3–12)	66	14		63	20
Progesterone receptor status
	negative (IRS 0–2)	51	7	0.000	104	51	0.004
	positive (IRS 3–12)	110	48		51	12
HER2 IHC
	weak (0–2+)	126	48	0.044	133	38	0.014
	strong (3+)	31	17		31	15
GLI1^c
	low (IRS 0–6)	66	15	0.019	64	23	0.102
	high (IRS 7–12)	120	49		116	53

^aAccording to UICC: TNM classification of malignant tumours. 6^th edn (2002) Sobin LH, Wittekind CH (eds) Wiley: New York
^bLog rank test (two-sided), bold face representing significant data (P < 0.05)
^cGLI1 nuclear immunoreactivity: low = IRS 0–6, high = IRS 7–12

ISSN: 1471-2407