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Figure 3 | BMC Cancer

Figure 3

From: Expression of the glioma-associated oncogene homolog (GLI) 1in human breast cancer is associated with unfavourable overall survival

Figure 3

Immunohistochemical expression analysis of GLI1 protein in normal breast tissue, non-invasive and invasive breast tumours using a TMA. (A, B) In normal breast tissue low levels of GLI1 expression are detectable in the cytoplasm (median IRS = 4) and in the nucleus (median IRS = 6). In ductal carcinomas in situ of high grade type (C, D) as well as in invasive breast carcinomas (E, F) nuclear GLI1 expression is more intense than in normal breast tissues (median IRS = 8), whereas the cytoplasmic GLI1 expression is weak (median IRS = 3). (G, H) Representative tissue section from human basal cell carcinoma which served as a positive control for GLI1 staining. (I, J) Negative control – benign breast tissue. Magnifications: A, C, E, G, I: 100×; B, D, F, H, J: 400×.

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