Table 2 Plexin D1 expression in pre-malignant and non-tumor related tissues.
From: Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies
Tissue | PLXND1 expression | Remarks | ||
|---|---|---|---|---|
| Â | Endothelial cells | Subsets of macrophages | Subsets of fibroblasts | Â |
Pre-malignant samples | Â | Â | Â | Â |
Ductal carcinoma in situ of breast (n = 5) | + | + | + | Weak staining of tumor cells |
Lobular carcinoma in situ of breast (n = 3) | Weak | + | + | Weak staining of tumor cells |
Vulvar intraepithelial neoplasia (VIN) | Â | Â | Â | Â |
   Classic VIN III, HPV negative (n = 5) | - | + | + |  |
   Classic VIN III, HPV positive (n = 8) | - | + | + |  |
   Differentiated VIN III (n = 8) | - | + | n.d. |  |
Non-tumor related samples | Â | Â | Â | Â |
Bladder (n = 1) | - | + | - | Â |
Blood vessel | Â | Â | Â | Â |
   Atherosclerosis (n = 6) | - | + | - |  |
   Fatty streaks (n = 1) | - | + | - |  |
Bone marrow (n = 2) | n.d. | - | - | Â |
Brain | Â | Â | Â | Â |
   Cortex (n = 1) | - | n.d. | n.d. | Some neurons perinuclear staining |
   Alzheimer and CAA (n = 1) | - | n.d | n.d. |  |
   Multiple Sclerosis (n = 2) | - | n.d | n.d. |  |
Breast | Â | Â | Â | Â |
   Normal breast (n = 2) | - | - | - | Some epithelial cells perinuclear staining |
   Ductal hyperplasia (n = 1) | - | + | - | Focal epithelial cells perinuclear staining |
Endometrium | Â | Â | Â | Â |
   Proliferation phase (n = 5) | Subset (n = 3) | + | n.d. |  |
   Secretion phase (n = 4) | - | + | n.d. |  |
   Secretion/menstruation phase (n = 1) | - | + | n.d. |  |
   Endometriosis interna (n = 1) | - | + | n.d. |  |
Heart (n = 1) | - | n.d | n.d | Myocytes perinuclear staining |
Large intestine (n = 1) | - | + | + | Some epithelial cells perinuclear staining |
Liver (n = 1) | - | + | n.d. | Some hepatocytes perinuclear staining |
Lung (n = 2) | - | + | n.d. | Â |
Oesophagus (n = 1) | - | + | - | Â |
Pancreas (n = 1) | - | n.d | n.d. | Perinuclear staining Islets of Langerhans |
Pituitary gland (n = 1) | - | n.d. | n.d. | Some epithelial cells perinuclear staining |
Prostate (n = 1) | - | - | n.d. | Some epithelial cells perinuclear staining |
Small intestine (n = 1) | - | + | + | Some epithelial cells perinuclear staining |
Spleen (n = 1) | - | + | n.d. | Â |
Thyroid gland (n = 1) | - | + | n.d. | Some epithelial cells perinuclear staining |
Vulva | Â | Â | Â | Â |
   Normal vulva (n = 6) | - | + | + |  |
   Lichen sclerosus (n = 6) | - | + | + |  |