Figure 1
From: Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies
PLXND1 expression in representative clinical tumor samples. Immunohistochemical analyses using a single domain antibody against PLXND1 (Magnification ×200). PLXND1 is abundantly expressed in adenocarcinoma brain metastases (A), glioblastomas multiforme (B), neuro-endocrine lung tumors (C), an ovarian adenocarcinoma (D), and prostatic urothelial cell carcinomas (E). The arrows point at PLXND1-positive vasculature. PLXND1 is absent in both tumor vasculature (arrowheads) and tumor cells in vulvar squamous cell carcinomas (F). The insets in A and B show corresponding PLXND1 mRNA in situ hybridization analyses (Magnification ×200).