Figure 4
From: Vasohibin inhibits angiogenic sprouting in vitro and supports vascular maturation processes in vivo
Effects of recombinant VASH1 proteins on blood vessel formation in the CAM assay. (A) Comparison of CAMs treated with 30 ng purified mVASH1 (n = 6), co-FLAG extract (n = 6) or 30 ng human VASH1 (n = 6). All blood vessels within the ring area (20 mm2) were counted. (B) Reduction of large vessels (diameter > 50 μm) in human and murine VASH1 treated CAMs. (C) Microvessels (diameter < 50 μm) were significantly increased in human and murine VASH1-treated CAMs. Stars indicate p values < 0.05. Controls indicate untreated CAMs (n = 6).