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Table 4 Ability of the FHS-7 to identify women with clinical criteria (family history) for hereditary breast cancer syndromes (n = 1795).

From: Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care

Criteria AUC (CI 95%) Cut point = 1
   Sensitivity (CI 95%) Specificity (CI 95%) PPV1(CI 95%) NPV2(CI 95%)
ASCO criteria3 0.85 (0.81–0.89) 97.0 (91–100) 52.0 (50–55) 7.0 (6–9) 100.0 (99–100)
High risk HBOC syndrome4 0.86 (0.82–0.90) 97.0 (92–100) 53.0 (50–55) 8.0 (7–10) 100.0 (99–100)
HBCC criteria3 0.86 (0.84–0.88) 100.0 (89–100) 51.0 (49–54) 3.0 (2–4) 100.0
LFL syndrome3 0.72 (0.68–0.76) 83.0 (77–88) 54.0 (52–56) 16.0 (14–18) 97.0 (96–98)
HBC syndrome (overall)5 0.83 (0.81–0.85) 88.0 (83–91) 56.0 (54–59) 24.0 (21–27) 97.0 (95–98)
  1. 1 PPV = positive predictive value.
  2. 2 NPV = negative predictive value.
  3. 3 Criteria as described in materials and methods.
  4. 4 ASCO criteria and/or estimated prior probability of a BRCA mutation ≥30%.
  5. 5 Includes Hereditary Breast and Ovarian Cancer (HBOC), Hereditary Breast and Colorectal Cancer (HBCC) and Li-Fraumeni-like syndrome (LFL) criteria.
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