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Table 3 Total number of women fulfilling different criteria for hereditary breast cancer syndromes in both study groups.

From: Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care

 

Women reporting a FH1 of cancer in PCU2 (n = 885)

Women with a negative FH1 for cancer in PCU2 (n = 910)

 

n

%

n

%

ASCO criteria for HBOC syndrome3

64

7.2

2

0.2

High risk HBOC syndrome4

75

8.5

2

0.2

HBCC criteria3

26

2.9

0

0.0

LFL syndrome3

141

16.0

29

3.2

HBC syndrome (overall)5

211

23.8

30

3.3

  1. 1 FH = Family History.
  2. 2 PCU = Primary Care Unit.
  3. 3 Criteria as described in materials and methods.
  4. 4 ASCO criteria and/or prior probability of a BRCA mutation ≥ 30% using Myriad mutation prevalence tables and the Penn II mutation prediction model.
  5. 5 Includes Hereditary Breast and Ovarian Cancer (HBOC), Hereditary Breast and Colorectal Cancer (HBCC) and Li-Fraumeni-like syndrome (LFL) criteria.
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BMC Cancer

ISSN: 1471-2407

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