Table 2 Several sets of Up-regulated and Down-regulated genes (p < 0.05) after FAK silencing with FAKsiRNA*

212094_at

PEG10

Paternally expressed 10

Proteolysis; apoptosis; differentiation

0.22

205239_at

AREG

Amphiregulin

Cell-cell signaling; proliferation

0.23

223062_s_at

PSAT1

Phosphoserine Aminotransferase 1

L-serine biosynthetic; metabolic; amino-acid biosynthetic processes

0.29

214467_at

GPR65

G protein-coupled receptor 65

Apoptosis; G-protein coupled receptor protein signaling pathway; immune response

0.31

238695_s_at

RAB39B

RAB39B, member RAS oncogene family

Transport; small GTPase mediated signal transduction; protein transport

0.39

239014_at

CCAR1

Cell division cycle and apoptosis regulator 1

Apoptosis; cell cycle; cell division

0.42

231879_at

COL12A1

Collagen, type XII, alpha 1

Skeletal development; phosphate transport; cell adhesion; collagen fibril organization

0.44

203424_s_at

IGFBP5

Insulin-like growth factor binding protein 5

Regulation of cell growth; signal transduction

0.49

235412_at

ARHGEF7

Rho guanine nucleotide exchange factor (GEF)7

Regulation of Rho protein signal transduction; intracellular signaling cascade

0.52

216765_at

MAP2K5

Mitogen-activated protein kinase kinase 5

Protein amino acid phosphorylation; signal transduction

0.61

223746_at

STK4

Serine/threonine kinase 4

Cell morphogenesis; protein amino acid phosphorylation; apoptosis kinase cascade

0.65

1559529_at

PTK2

PTK2 protein tyrosine

kinase 2

Protein amino acid phosphorylation; integrin-mediated signaling pathway; signal complex assembly

0.68

205397_x_at

SMAD3

SMAD family member 3

SMAD protein complex assembly; regulation of transcription from RNA polymerase II promoter

0.70

204214_s_at

RAB32

RAB32, member RAS oncogene family

Small GTPase mediated signal transduction; Protein transport

1.52

204794_at

DUSP2

Dual specificity phosphatase 2

Inactivation of MAPK activity; Protein amino acid dephosphorylation

1.86

206898_at

CDH19

Cadherin 19, type 2

Cell-cell adhesion; cell adhesion

2.42

201117_s_at

CPE

Carboxypeptidase E

Neuropeptide signaling pathway; Insulin processing; metabolic process

2.64

205749_at

CYP1A1

Cytochrome P450, family 1, subfamily A, polypeptide 1

Dibenzo-p-dioxin metabolic process;

oxidation reduction

2.97

201010_s_at

TXNIP

Thioredoxin interacting protein

Transcription; cell cycle; keratinocyte differentiation

3.26

232306_at

CDH26

Cadherin-like 26

Cell adhesion

4.05

205792_at

WISP2

WNT1 inducible signaling pathway protein 2

Cell growth; adhesion; signal transduction

4.09

207173_x_at

CDH11

Cadherin 11, type 2, OB-cadherin (osteoblast)

Skeletal development; adhesion; ossification

4.12

204653_at

TFAP2A

Transcription factor AP-2 alpha

Transcription; signal transduction

4.99

228697_at

HINT3

Histidine triad nucleotide binding protein 3

Signal transduction

5.33

229700_at

ZNF738

Zinc finger protein 738

Regulation of transcription

8.7

205051_s_at

KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Protein amino acid phosphorylation; signal

Transduction; epithelial proliferation

12.59