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Table 2 Several sets of Up-regulated and Down-regulated genes (p < 0.05) after FAK silencing with FAKsiRNA*

From: The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis

  Down-regulated genes  
Probeset ID Gene Symbol Gene name Gene Ontology (GO) Biological process Fold change siRNA/Control
212094_at PEG10 Paternally expressed 10 Proteolysis; apoptosis; differentiation 0.22
205239_at AREG Amphiregulin Cell-cell signaling; proliferation 0.23
223062_s_at PSAT1 Phosphoserine Aminotransferase 1 L-serine biosynthetic; metabolic; amino-acid biosynthetic processes 0.29
214467_at GPR65 G protein-coupled receptor 65 Apoptosis; G-protein coupled receptor protein signaling pathway; immune response 0.31
238695_s_at RAB39B RAB39B, member RAS oncogene family Transport; small GTPase mediated signal transduction; protein transport 0.39
239014_at CCAR1 Cell division cycle and apoptosis regulator 1 Apoptosis; cell cycle; cell division 0.42
231879_at COL12A1 Collagen, type XII, alpha 1 Skeletal development; phosphate transport; cell adhesion; collagen fibril organization 0.44
203424_s_at IGFBP5 Insulin-like growth factor binding protein 5 Regulation of cell growth; signal transduction 0.49
235412_at ARHGEF7 Rho guanine nucleotide exchange factor (GEF)7 Regulation of Rho protein signal transduction; intracellular signaling cascade 0.52
216765_at MAP2K5 Mitogen-activated protein kinase kinase 5 Protein amino acid phosphorylation; signal transduction 0.61
223746_at STK4 Serine/threonine kinase 4 Cell morphogenesis; protein amino acid phosphorylation; apoptosis kinase cascade 0.65
1559529_at PTK2 PTK2 protein tyrosine kinase 2 Protein amino acid phosphorylation; integrin-mediated signaling pathway; signal complex assembly 0.68
205397_x_at SMAD3 SMAD family member 3 SMAD protein complex assembly; regulation of transcription from RNA polymerase II promoter 0.70
  Up-regulated genes  
204214_s_at RAB32 RAB32, member RAS oncogene family Small GTPase mediated signal transduction; Protein transport 1.52
204794_at DUSP2 Dual specificity phosphatase 2 Inactivation of MAPK activity; Protein amino acid dephosphorylation 1.86
206898_at CDH19 Cadherin 19, type 2 Cell-cell adhesion; cell adhesion 2.42
201117_s_at CPE Carboxypeptidase E Neuropeptide signaling pathway; Insulin processing; metabolic process 2.64
205749_at CYP1A1 Cytochrome P450, family 1, subfamily A, polypeptide 1 Dibenzo-p-dioxin metabolic process; oxidation reduction 2.97
201010_s_at TXNIP Thioredoxin interacting protein Transcription; cell cycle; keratinocyte differentiation 3.26
232306_at CDH26 Cadherin-like 26 Cell adhesion 4.05
205792_at WISP2 WNT1 inducible signaling pathway protein 2 Cell growth; adhesion; signal transduction 4.09
207173_x_at CDH11 Cadherin 11, type 2, OB-cadherin (osteoblast) Skeletal development; adhesion; ossification 4.12
204653_at TFAP2A Transcription factor AP-2 alpha Transcription; signal transduction 4.99
228697_at HINT3 Histidine triad nucleotide binding protein 3 Signal transduction 5.33
229700_at ZNF738 Zinc finger protein 738 Regulation of transcription 8.7
205051_s_at KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Protein amino acid phosphorylation; signal Transduction; epithelial proliferation 12.59
  1. * The complete set of genes down-regulated or up-regulated by FAKsiRNA with p < 0.05 are up-loaded to NCBI database (NCBI Accession number GSE11581).