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Table 1 Fold changes of mRNA expression levels in MCF-7-Tet-ON cell lines cultivated in the presence or absence of doxycycline (2 μg/ml) for 6 days

From: The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis

Gene Symbol Dox+/Dox- Ratio
  Tre-2 FAK FAK-CD
PTK2 0.59 1.86 * 0.82
PTK2B 0.82 0.85 0.64
p53 0.99 0.66 0.85*
DMTF1 1.20 0.65* 0.81
SRC 1.95 0.76 0.87
MAPK3 1.05 0.74 0.97
AKT1 0.56 0.58 0.73
MAP2K1 0.57 0.52* 0.52
MAPK8 0.70 0.61* 0.85*
FYN 0.84 0.33* 0.65*
CDC2 0.72 1.02 0.82*
CDK4 0.94 0.88* 0.94*
RB1 0.88 0.48* 0.60*
SOCS2 1.12 0.65* 1.20*
SYK 0.66 0.47* 0.63*
CDK2 0.97 0.93* 0.73
CDK3 0.80 0.71 0.74
RAF1 0.78 0.60* 0.54*
ABL1 0.63 0.66 0.78*
TEC 0.67 0.63* 0.58*
PXN 0.96 0.62* 0.75*
SHC1 0.98 0.62* 0.78
BCAR1 0.62 0.53 0.70
MAK2K6 0.76 1.04 1.73*
EPHA1 0.56 0.78 0.75
CTNNB1 0.80 0.56* 0.70*
CHEK1 0.75 0.62* 0.62*
ATM 1.09 0.65 0.99
BIRC5 0.93 0.88 0.74
CDC25C 1.27 1.05 1.18
BCL2 0.31 0.30 0.37
TLN2 0.72 0.81* 0.65*
FLT1 0.33 0.37 0.46
PINK1 1.18 0.51* 0.65*
STAT1 0.70 0.54* 0.46
ARHGEF2 0.75 0.56 0.73
ITGB1 0.46 0.52* 0.65*
CELSR1 1.26 0.88 0.79
LAMC2 0.64 0.38* 0.64*
  1. *p < 0.05, t-test; ** mRNA levels of some genes from Additional file 1 was not detectable