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Table 1 Fold changes of mRNA expression levels in MCF-7-Tet-ON cell lines cultivated in the presence or absence of doxycycline (2 μg/ml) for 6 days

From: The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis

Gene Symbol

Dox+/Dox- Ratio

 

Tre-2

FAK

FAK-CD

PTK2

0.59

1.86 *

0.82

PTK2B

0.82

0.85

0.64

p53

0.99

0.66

0.85*

DMTF1

1.20

0.65*

0.81

SRC

1.95

0.76

0.87

MAPK3

1.05

0.74

0.97

AKT1

0.56

0.58

0.73

MAP2K1

0.57

0.52*

0.52

MAPK8

0.70

0.61*

0.85*

FYN

0.84

0.33*

0.65*

CDC2

0.72

1.02

0.82*

CDK4

0.94

0.88*

0.94*

RB1

0.88

0.48*

0.60*

SOCS2

1.12

0.65*

1.20*

SYK

0.66

0.47*

0.63*

CDK2

0.97

0.93*

0.73

CDK3

0.80

0.71

0.74

RAF1

0.78

0.60*

0.54*

ABL1

0.63

0.66

0.78*

TEC

0.67

0.63*

0.58*

PXN

0.96

0.62*

0.75*

SHC1

0.98

0.62*

0.78

BCAR1

0.62

0.53

0.70

MAK2K6

0.76

1.04

1.73*

EPHA1

0.56

0.78

0.75

CTNNB1

0.80

0.56*

0.70*

CHEK1

0.75

0.62*

0.62*

ATM

1.09

0.65

0.99

BIRC5

0.93

0.88

0.74

CDC25C

1.27

1.05

1.18

BCL2

0.31

0.30

0.37

TLN2

0.72

0.81*

0.65*

FLT1

0.33

0.37

0.46

PINK1

1.18

0.51*

0.65*

STAT1

0.70

0.54*

0.46

ARHGEF2

0.75

0.56

0.73

ITGB1

0.46

0.52*

0.65*

CELSR1

1.26

0.88

0.79

LAMC2

0.64

0.38*

0.64*

  1. *p < 0.05, t-test; ** mRNA levels of some genes from Additional file 1 was not detectable
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BMC Cancer

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