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Table 3 Toxicity

From: A non-randomized comparison of gemcitabine-based chemoradiation with or without induction chemotherapy for locally advanced squamous cell carcinoma of the head and neck

 

CRT

ST

 

n = 27

n = 31

 

% (grade 3/4)

% (grade 3/4)

During induction chemotherapy

  

   Anemia

NA

100 (19)

   Neutropenia

NA

94 (90)

   Thrombocytopenia

NA

74 (13)

   Mucositis

NA

13 (6)

   Fatigue

NA

61 (3)

   Diarrhea

NA

6 (3)

During chemoradiation

  

   Anemia

100 (4)

97 (16)

   Neutropenia

41 (4)

58 (13*)

   Thrombocytopenia

30 (0)

61 (6)

   Mucositis

100 (81)

100 (97)

   Dermatitis

100 (74)

100 (42)

   Weigth loss > 5%

63

69

> 10%

30

28

Tube feeding during CRT

81

97

at 1 year**

0

33***

  1. *: 1 patient grade 5; **in patients alive without locoregional recurrence
  2. ***: 4/10 oropharynx and 3/5 hypopharynx; NA = not applicable