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Table 3 Toxicity

From: A non-randomized comparison of gemcitabine-based chemoradiation with or without induction chemotherapy for locally advanced squamous cell carcinoma of the head and neck

  CRT ST
  n = 27 n = 31
  % (grade 3/4) % (grade 3/4)
During induction chemotherapy   
   Anemia NA 100 (19)
   Neutropenia NA 94 (90)
   Thrombocytopenia NA 74 (13)
   Mucositis NA 13 (6)
   Fatigue NA 61 (3)
   Diarrhea NA 6 (3)
During chemoradiation   
   Anemia 100 (4) 97 (16)
   Neutropenia 41 (4) 58 (13*)
   Thrombocytopenia 30 (0) 61 (6)
   Mucositis 100 (81) 100 (97)
   Dermatitis 100 (74) 100 (42)
   Weigth loss > 5% 63 69
> 10% 30 28
Tube feeding during CRT 81 97
at 1 year** 0 33***
  1. *: 1 patient grade 5; **in patients alive without locoregional recurrence
  2. ***: 4/10 oropharynx and 3/5 hypopharynx; NA = not applicable