Forest plot of relative risks in patients with bone metastases from breast cancer. Significant covariates for (A) overall survival, (B) first SRE, first pathologic fracture, and first radiation to bone. The relative risk for each covariate was derived from reduced multivariate analyses. Lines represent 95% confidence intervals. PR = Progesterone receptor, SRE = Skeletal-related event, BALP = Bone-specific alkaline phosphatase, ECOG = Eastern Cooperative Oncology Group.