Table 3 Risk of UGI cancer by FH of malignant tumor in first degree relatives and non-blood relatives*

First degree relative

334(22)

197(33)

1.72(1.39–2.12)

162(27)

1.32(1.06–1.64)

94(30)

1.52(1.15–1.99)

1 affected

294(19)

160(27)

1.58(1.26–1.98)

135(22)

1.25(0.99–1.58)

79(25)

1.43(1.07–1.92)

≥ 2 affected

40(3)

37(6)

2.76(1.73–4.40)

27(5)

1.83(1.10–3.03)

15(5)

2.15(1.16–3.98)

P trend

<0.001

0.005

0.001

Male

233(21)

126(34)

2.00(1.50–2.54)

132(27)

1.35(1.05–1.73)

78(33)

1.83(1.34–2.49)

Female

101(25)

71(32)

1.40(0.98–2.02)

30(28)

1.24(0.76–2.01)

16(21)

0.81(0.44–1.48)

< 50 yr

59(22)

41(38)

2.17(1.32–3.56)

22(33)

1.95(1.06–3.58)

28(36)

2.39(1.35–4.25)

≥ 50 yr

275(22)

156(32)

1.61(1.27–2.04)

140(26)

1.25(0.98–1.58)

66(28)

1.35(0.98–1.85)

Non-blood relative

58(4)

26(4)

1.08(0.66–1.76)

25(4)

1.02(0.62–1.66)

6(2)

0.61(0.26–1.46)

First degree relative

170(11)

131(22)

2.28(1.77–2.95)

104(17)

1.62(1.24–2.12)

53(17)

1.65(1.17–2.33)

1 affected

162(11)

114(19)

2.08(1.59–2.71)

88(15)

1.43(1.08–1.90)

46(14)

1.50(1.05–2.15)

≥ 2 affected

8(1)

17(3)

6.37(2.82–15.6)

16(3)

5.35(2.26–12.7)

7(2)

4.78(1.68–13.6)

P trend

<0.001

<0.001

0.001

Male

124(11)

88(23)

2.59(1.90–3.54)

87(18)

1.66(1.23–2.23)

45(19)

1.89(1.29–2.77)

Female

46(11)

43(19)

1.85(1.16–2.92)

17(16)

1.52(0.82–2.80)

8(10)

0.98(0.43–2.20)

< 50 yr

34(12)

23(21)

1.84(1.01–3.35)

10(15)

1.23(0.56–2.68)

17(22)

2.34(1.18–4.65)

≥ 50 yr

136(11)

108(22)

2.37(1.78–3.16)

94(18)

1.70(1.28–2.27)

36(15)

1.51(1.01–2.26)

Non-blood relative

26(2)

12(2)

1.11(0.54–2.24)

13(2)

1.17(0.59–2.32)

3(1)

0.73(0.22–2.45)

First degree relative

97(6)

95(16)

2.84(2.09–3.86)

52(9)

1.34(0.94–1.91)

28(9)

1.56(0.99–2.43)

1 affected

93(6)

83(14)

2.53(1.84–3.50)

43(7)

1.15(0.79–1.68)

25(8)

1.44(0.90–2.30)

≥ 2 affected

4(0.3)

13(2)

10.0(3.24–31.2)

9(2)

5.75(1.74–19.0)

3(1)

4.54(0.96–21.6)

P trend

<0.001

0.022

0.026

Father

52(3)

40(7)

2.01(1.31–3.10)

23(4)

1.06(0.64–1.76)

13(4)

1.27(0.68–2.38)

Mother

29(2)

34(6)

3.27(1.96–5.47)

19(3)

1.69(0.93–3.07)

14(4)

2.52(1.30–4.89)

Sibling

21(1)

35(6)

4.66(2.67–8.13)

20(3)

2.36(1.26–4.41)

4(1)

1.14(0.38–3.40)

Non-blood relative

9(0.6)

7(1)

1.86(0.68–5.10)

6(1)

1.49(0.52–4.26)

1(0.3)

0.76(0.09–6.16)

25(2)

23(4)

2.45(1.37–4.39)

28(5)

2.87(1.65–5.00)

12(4)

2.35(1.16–4.79)

51(3)

19(3)

0.95(0.56–1.64)

31(5)

1.54(0.97–2.44)

17(5)

1.52(0.86–2.69)

First degree relative

164(11)

66(11)

0.98(0.72–1.33)

58(10)

0.92(0.67–1.27)

41(13)

1.22(0.84–1.76)

Non-blood relative

32(2)

14(2)

1.05(0.55–2.01)

12(2)

0.90(0.46–1.77)

3(1)

0.54(0.16–1.80)