Figure 1From: Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas Copy numbers of BCCIP exons detected by quantitative Real-Time PCR. The copy number of exons 5, 6, 7, and 9 were measured in 10 cases of normal brain tissue DNA (diamond marker), and 45 cases of glioblastoma DNA (see Materials and Methods for details). The 95% and 99% confidence ranges of the copy number in normal tissues are marked. Many tumor DNAs showed reduction of BCCIP copy numbers. However, five cases of tumor DNA (marked as cases A-E) have reduced BCCIP copy numbers at some exons but increased in others. These re-arrangements likely cause inactivation of the BCCIP gene.Back to article page